Martin Petrenko, Viera Oroszová, Zuzana Nižňanská, Ingrid Rejdová
Syndrome Mayer-Rokitansky-Küster-Hauser is a pathological malformation of internal genital organs characterized by the missing uterus and variable aplasia of the upper portion of the vagina connected with primary amenorrhoea and infertility. Presence of karyotype 46, XX leads to the development of physiological secondary sexual signs. Aetiologically it might be a consequence of insufficient development of Müllerian ducts between the 5th and 6th week of pregnancy. Specific mutations of several genes as a WT1, PAX2, HOXA7 ‒ HOXA13, PBX1 a WNT4 also TCF2 (HNF1B) and LHX1 activated in the initial phase of embryonic development could have played a key role in aetiopathogenesis of this syndrome. Surgical and non-surgical therapeutic alternatives of this pathology are available at present. The main principle of non-surgical methods is progressive dilatation of space between the bladder and rectum. Most common surgical techniques are operations developed by McIndoe, Williams, Vecchietti, Davydov and Baldwin. The aim of this article is to pay attention to complications of laparoscopic neovagina formation.