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Časopis Gynecology for practice – Článok Genetic basis of gestational trophoblastic disease

Gynecology for practice

Reviewed, postgraduate scietific medical journal.
Period 4x per year
1336-3425
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gynecology for practice
Gynecology for practice
Reviewed, postgraduate scietific medical journal.
Period 4x per year
Predplatné
Téma: 

Genetic basis of gestational trophoblastic disease

Ján Vojtaššák, Branislav Vojtaššák

Gestational trophoblastic disease is a very heterogenic group of lesions from benign to malignant ones. It is a unique form of pathologic embryonic development caused by the absence of the whole or only of a part of maternal nuclear genome. Many benign and malignant forms belong to this disease. The benign form usually arises in the moment of fertilization or in the first hours of existence, with the exception of familial recurrent biparental hydatidiform moles. The reason to it is the unavailability of specific genetic information coded by maternal nuclear genome needed for development of an embryo. This information is absent or chemically so modified, that it is not available. Majority of malignant forms arises from previous molar pregnancy what could be proved by genetic analysis. But they arise also after physiological pregnancy, spontaneous abortion or ectopic pregnancy. Trophoblast cells with the ability of controlled invasion into the surrounding tissue at the place of implantation as well as their transport by blood vessels, usually into the lungs of pregnant woman are the reason. The accidental subsequent mutations in the system of the cell cycle regulation of such trophoblast cells could start the process of malignant transformation resulting into the gestational trophoblastic neoplasia and explain also the specific features of therapy.

hydatidiform mole, gestational trophoblastic tumours, cytogenetic, molecular biology, malignant transformation
Gynekol. prax 2014; 12 (3): 145-149

Ročník 2014  Témy časopisu Gynecology for practice 3 / 2014

Filip Hron, Jaroslav Feyereisl, Miloš Zavadil †
Miroslav Korbeľ, Jozef Šufliarsky, Ľudovít Danihel, Ján Vojtaššák, Zuzana Nižňanská
Jozef Šufliarsky, Miroslav Korbeľ, Ivica Bartošová, Ivan Koza, Michaela Kubičková, Andrej Jurík, Tomáš Minárik, Ľubomír Bohunický
Filip Hron, Miroslav Korbeľ, Jaroslav Feyereisl, Petr Šafář
Ján Vojtaššák, Branislav Vojtaššák
Ľudovít Danihel, Zuzana Čierna, Kristína Kuracinová, Vladimír Šišovský, Michal Palkovič, Ľudovít Danihel ml.
Miroslav Korbeľ, Zuzana Nižňanská, Filip Hron
Marína Paulovičová, Jana Andrisová, Zuzana Líšková

Case Studies

Miroslav Korbeľ, Jozef Šufliarsky, Ľudovít Danihel, Zuzana Nižňanská, Ján Vojtaššák

Original Works

Miloš Jeseňák, Anna Šujanská, Oľga Červeňová, Peter Bánovčin
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Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
MUDr. Tibor Bielik PhD.

MEMBERS OF THE EDITORIAL BOARD
prof. MUDr. Miroslav Borovský, CSc.
prof. MUDr. Ján Danko, CSc.
prof. MUDr. Ľudovít Danihel, PhD.
doc. MUDr. Ivan Hollý, PhD.
MUDr. Ľudovít Janek st.
doc. MUDr. Miroslav Korbeľ, CSc.
prof. MUDr. Štefan Lukačín, PhD.
prof. MUDr. Miloš Mlynček, CSc.
MUDr. Zuzana Nižňanská, PhD.
doc. MUDr. Martin Redecha, PhD.

PROFESSIONAL EDITOR
doc. MUDr. Martin Redecha, PhD.

EDITOR-IN-CHIEF
Ing. Danica Paulenová
e-mail: paulenova@amedi.sk

GRAPHIC LAYOUT AND TYPESETTING
Lucia Vecseiová
e-mail: dtp@amedi.sk

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PROOFREADING OF ENGLISH TEXTS
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SECTIONS

OVERVIEW PAPERS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy. Maximum size is 8 pages (font size 12, line spacing 1.5) with maximum five pictures (graphs). In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office. Write the article with emphasis on its practical usage for gynaecologists.

CASE STUDY
Maximum extent is 7 pages. Structuring: summary, key words
(also in English), introduction, case study, discussion, conclusion, bibliography.

DIAGNOSTIC AND THERAPEUTICAL ALGORITHMS
Diagnosis and therapy processed into tables and schemes, with minimum text, with emphasis to conciseness and clarity.

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FROM BORDERLINE OF GYNECOLOGY
Intersectional theme elaborated complexly, well-arranged, clear (extent up to 8 pages).


MANUSCRIPT ELABORATION

Write the paper on computer in any common text editor.
- write full length of lines (do not use ENTER at the end of a line)
- do not arrange text into columns
- do not do page make-up, put tables at the end of the paper
- distinguish precisely numbers 1, 0 and letters l, O
- use always parentheses ( )
- explain abbreviations always when first used


MANUSCRIPT REQUIREMENTS

1. An accurate paper title, names and surnames of all authors including titles, authors` workplace. The first author address including the phone number, fax and e-mail address.
2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies and From borderline of gynaecology). Write in 1st or 3rd person singular or plural (unify according the type of an article).
3. Key words - in the extent of 3-6 (just at overview papers, From borderline of cardiology).
4. English translation: paper title, summary, key words (only at overview papers, From borderline of gynaecology and case studies)
5. Text
If you insert pictures into a document, send also their original files in "jpg" format, create graphs in Excel and send also their original files. If you send photo documentation via post office, please, send just high-class originals. Mark each original by a number, under which it is mentioned in the text. Write in 1st or 3rd person singular or plural (unify according the type of an article).
6. Bibliography
Citations are numbered chronologically in bold, references in the text are stated by the number of citations in parentheses. Use maximum 20 citations.

Examples of citations:
1. Webb MJ. Chirurgia v gynekologickej onkológii – včera, dnes a zajtra. Gynekol prax 2003; 1 (1): 29-34.
2. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.
3. Kistner RW. Gynecology. Principles and Practice. 3rd Ed. Chicago: Year Book Medical Publisher 1979: 823p.
4. Osborne BE.The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.
5. Rodička a novorodenec 2000. Zdravotnická statistika, ÚZIS ČR 2001, 127.
6. http/www.nspnz.sk/neonatal/priority.htm

Do not use dots after first names in citations. Do not use colon but dot after names of authors. Use semi-colon after the year of publishing, colon is before pages. If an author is one, two or three - it is necessary to state all. If there are more than three authors it is necessary to write first three and "et all",. If there are more than three authors it is necessary to write first three and "et all", in Slovak and Czech citations "a spol.".

Due to publishing of autodidactic tests it is necessary to add 4 questions to your article and 4 answers with marking of one correct answer, e.g.:

For primary dysmenorrhoea from laboratory results it is characteristic:
a. increase of lymphocytes in differential BP over 40 %
b. increase of C-reactive protein and FW in the blood
c. decrease of Hb level in the blood below 100 g/l
d. none of them are characteristic

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are double reviewed.

All published papers are paid.

Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-patient gynaecological practice.

Send contributions by e-mail to the address: paulenova@amedi.sk
Period 4x per year
1336-3425
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gynecology for practice
Gynecology for practice
Reviewed, postgraduate scietific medical journal.
Period 4x per year
Predplatné