Petr Křepelka
Combined hormonal contraception is one of the most effective methods of preventing unwanted pregnancy. The process of finding new dosage forms has led to the development from oral contraceptives to non-oral forms, transdermal contraceptive patches and vaginal inserts. Non-oral forms of combined hormonal contraceptives show a higher degree of compliance and thus greater; they efficacy compared to oral contraceptives. Non-oral forms of combined hormonal contraceptives are not burdened by the so-called first-pass effect. They affect glucose and lipids metabolism and synthesis of procoagulant factors significantly less. Although these effects are laboratory proven, the incidence of serious adverse events such as deep vein thrombosis, pulmonary embolism, and arterial atherosclerosis is comparable to those seen in oral contraceptives users.