Téma: Original Works

Risk factors of cognitive dysfunction of patients with acute cerebral stroke

David Školoudík, Táňa Fadrná, Milada Sedláková, Pavel Ressner, Michal Bar, Olga Zapletalová, Roman Herzig, Petr Kaňovský

Patients with acute cerebral stroke often suffer from significant worsening of their cognitive functions resulting not only from brain affliction but also from other factors. The aim of our study was to find out the dependence of cognitive dysfunction in patients with acute cerebral stroke in the first week from the onset of symptoms on age, gender, type, severity and localization of the damage of the brain, infection and acute disease. Methods: The pilot study involved all patients with cerebral stroke admitted to Neurological Clinic. Control group (CG) consisted of patients with acute coronary syndrome without symptoms of affliction of the central nervous system. All patients with acute cerebral stroke were tested for cognitive functions by means of mini mental state examination and by test of hours 2., 7. and 90th day. Results: The study involved 30 patients with cerebral stroke - 17 men and 13 women, mean age 69.0 ± 11.3 yeras. Seven patients died within 90 days (23.3 %). Control group involved 15 patient with acute coronary syndrome - 10 men (66.7 %) and 5 women, mean age 69.8 ± 11.5 years (53 - 83 years). Pathological result of MMSE or CDT in the first week from the onset of symptoms was recorded in 73 % of patients with cerebral stroke and 27 % of patients in KS (p < 0.01). Significant negative affect of age, affliction of the central nervous system and its severity, acute disease, presence of fatic defect and infection to cognitive functions in the first week of the illness was demonstrated (p < 0.05). Affect of lesion location and gender to cognitive functions was not demonstrated (p > 0.05).Conclusion: Cognitive disorders can be detected in many patients with acute cerebral stroke. Risk factors for affliction of cognitive functions involve not only brain tissues damage but also higher age, presence of fatic defect, presence of infection and larger neurological deficit at the onset of cerebral stroke. Cognitive deficit in acute phase of cerebral stroke is linked with higher mortality.

Ročník 2006  Témy časopisu Neurology 1 / 2006

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