Téma: Original Works

Mitoxanthrone in therapy of advanced multiple sclerosis

Georgi Krastev, Juraj Tóth, Miroslav Mako

Multiple sclerosis is a progressive autoimmune disease with present demyelinization of CNS nerve cells. Mitoxanthrone is an immunosuppressive agent with detectable reduction of disease activity. It is an efficient sort of therapy mainly in later stages of the disease. We prepared data from 16 patients, whose EDSS had increased at least in one point during last 18 months before the therapy with mitoxanthrone started. It is a retrospective uncontrolled study. The patients received mitoxanthrone in total dose of 60 - 120 mg, the therapy lasted for 6 - 15 months. We scored the effect on disease progression (EDSS) and number of relapses during the therapy, 12 months and 24 months after finishing the therapy.We observed improvement, although not significant. Moreover, 2 years after finishing the therapy we confirmed that mitoxanthrone had holding effect in a half of patients regarding the EDSS and activity of the disease. Results, though obtained retrospectively, are comparable with preliminary studies.

Ročník 2006  Témy časopisu Neurology 1 / 2006

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MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
MUDr. Vladimír Nosáľ, PhD.
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prof. MUDr. Bruno Rudinský, CSc.
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prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
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Examples of citations:
1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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Which of following factors is not related to rosacea?
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d. endothelial growth factor

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