Téma:  Case Studies

Classification of sporadic form of creutzfeldt - jacob disease. retrospective analysis of a group of patients from 2002 to 2006.

Jozef Haring ml., Georgi Krastev

Creutzfeldt - Jacob disease (CJD) is fatal progressive neurodegenerative disease, belonging to the group of transmissible human spongiform encephalopathies. It is caused by multiplication and cumulation of pathologic prion proteins PrPres in human brain. Sporadic CJD is the most common form, its etiology is unknown, and incidence is approximately 1 to 1.5 cases in million people. Clinical symptoms are various, imitating other diseases. Patients between 45 and 75 years are affected; men and women are affected in the same ratio, leading to death in 6 months. In retrospective analysis of 17 patients with suspicion of CJD between 2002 and 2006 we decided to apply Poser,s diagnostic criteria, including protein 14-3-3 and typical MRI findings. We tried to investigate how these additional criteria are specific for our group of patients as a diagnostic marker of sCJD already during life. We found out high specificity of typical MRI findings – hyperintensive signal of nc. caudatus and putamen and also some cortical structures of brain and sensitivity of protein 14-3-3, in correlation with already published studies.

Ročník 2007  Témy časopisu Neurology 1 / 2007

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doc. MUDr. Robert Mikulík,Ph.D., FESO
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prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
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1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Which of following factors is not related to rosacea?
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