Téma: Overview works

Polymyositis – pathogenesis, diagnosis and therapy

Peter Špalek

Polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM) are three major catogories of idiopathic inflammatory myopathies. These disorders are clinically, histologically, and pathogenically distinct. Imumunopathogenically is PM T-cell-mediated disorder directed against muscle fibers. PM generally presents in patients over the age of 20 years and is more prevalent in females. Patients present with neck flexor weakness and symmetrical proximal arm and leg weakness, which develops over several weeks or months. Bohan´s and Peter´s clinical, biochemical, EMG and histopathological criteria are practical and sensitive for diagnosis of PM. The course of PM is mostly chronic and may require long-term therapy. PM is usually responsive to corticosteroids (prednisone is the treatment of choice in PM) and to immunosuppressive agents (azathioprine, cyclophosphamide, etc). In cases of PM refractory to corticosteroids and immunosuppressive agents has IVIg a beneficial response.

Ročník 2007  Témy časopisu Neurology 2 / 2007

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doc. MUDr. Miroslav Brozman, CSc.

MEMBERS OF THE EDITORIAL BOARD
MUDr. František Cibulčík, CSc.
doc. MUDr. Eleonóra Klímová, CSc.
doc. MUDr. Pavol Kučera, PhD.
MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
MUDr. Vladimír Nosáľ, PhD.
MUDr. Ľubica Procházková, CSc.
prof. MUDr. Bruno Rudinský, CSc.
doc. MUDr. Daniel Šaňák, Ph.D.
doc. MUDr. David Školoudík, Ph.D., FESO
prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
Dr. Milan R. Voško, PhD.

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Eva Stachová
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OVERVIEW PAPERS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy. Maximum size is 7 pages (font size 12, line spacing 1.5) with maximum 6 pictures (graphs). In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office. Write the article with emphasis on its practical usage for neurologists.

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DIAGNOSTIC AND THERAPEUTICAL ALGORITHMS
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MISCELLANEOUS
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1. An accurate paper title, names and surnames of all authors including titles, authors` workplace. The first author address including the phone number, fax and e-mail address.
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6. Bibliography
Citations are numbered chronologically in bold, references in the text are stated by the number of citations in parentheses. Use maximum 20 citations.

Examples of citations:
1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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Which of following factors is not related to rosacea?
a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

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