Téma: Overview works

Medication overuse headache (medication overuse headache, transformed migraine)

Peter Špalek

Medication overuse headache is considered to be the result of an interaction between an exposure (overuse of analgesics, triptans) and a biologically vulnerable individual (migraineur). In migraineurs, but not in individuals without migraine, medication overuse is a risk factor for chronic daily headaches. Therefore, medication overuse headache (transformed migraine) should be prevented. Potential strategies include limiting the use of acute medications to no more than 10 days per month and reducing headache frequency in migraineurs with preventive medication and non-pharmacological strategies, such as proper diet, weight loss, exercise, cognitive behavioral therapy, and education. In Europe and the USA, 30 - 80 % of the patients seen in a headache clinic have medication overuse headache. In individuals with established medication overuse headache treatment requires detoxification, „bridge therapy“ during detoxication, pharmacological and non-pharmacological preventive strategies, and education.

Ročník 2008  Témy časopisu Neurology 1 / 2008

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doc. MUDr. Eleonóra Klímová, CSc.
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MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
MUDr. Vladimír Nosáľ, PhD.
MUDr. Ľubica Procházková, CSc.
prof. MUDr. Bruno Rudinský, CSc.
doc. MUDr. Daniel Šaňák, Ph.D.
doc. MUDr. David Školoudík, Ph.D., FESO
prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
Dr. Milan R. Voško, PhD.

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1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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Which of following factors is not related to rosacea?
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d. endothelial growth factor

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