Téma: Overview works

magnetic resonance in diagnostics and treatment of multiple sclerosis

Miroslav Brozman

Magnetic resonance imaging (MRI) is the most important paraclinic test in diagnosis and monitoring of natural course and therapeutic measures of multiple sclerosis. MRI is considered the surrogate marker of multiple sclerosis. It is used in several clinical studies for diagnosis of onset and observation of progression of the disease, as well as for evaluation of different therapies. MRI enables monitoring of pathology of the disease during patient’s life by means of so called conventional MRI parameters (typical T2, T1 and gadolinium-enhancing lesions), and progression of cerebral atrophy. The main advantage of MRI is high sensitivity which enables to diagnose the disease very soon after first clinical manifestation. Disadvantage of MRI is low specificity of conventional MRI parameters and low correlation between MRI activity and progression of disability in MS patients. Non-conventional MRI techniques are able better to diagnose brain destruction and detect changes not only in white, but also in grey cerebral matter. It is considered that by combination of conventional and non-conventional MRI techniques in standardized diagnostic protocols we will be able to predict clinical course of the disease in individual patients and better evaluate the impact of several therapeutic measures.

Ročník 2008  Témy časopisu Neurology 1 / 2008

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doc. MUDr. Eleonóra Klímová, CSc.
doc. MUDr. Pavol Kučera, PhD.
MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
MUDr. Vladimír Nosáľ, PhD.
MUDr. Ľubica Procházková, CSc.
prof. MUDr. Bruno Rudinský, CSc.
doc. MUDr. Daniel Šaňák, Ph.D.
doc. MUDr. David Školoudík, Ph.D., FESO
prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
Dr. Milan R. Voško, PhD.

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Examples of citations:
1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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Which of following factors is not related to rosacea?
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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

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