Téma: Original Works

Treatment with statins and peripheral nervous system complications: results of prospective clinical and neurophysiologic surveillance

Pavel Otruba, Petr Kaňovský

The peripheral nervous system complications with statin treatment was prospectively investigated in a group of 42 patients (23 females, 19 males, mean ages 51.9 and 52.3 years, respectively). Initial examinations included laboratory and electrophysiological measures (peroneal and tibial nerves: MNCV, CMAP, F-wave; superficial peroneal and sural nerves: SNCV, SNAP), treatment with simvastatin 20 mg daily was initiated. Patients were followed for 24 months. Electrophysiological examination of lower-limb peripheral nerves demonstrated statistically significant prolongation of F-wave mean latency on the peroneal and tibial nerves (p < 0.0001). The study demonstrated that long-term treatment with statins may cause dysfunction of peripheral nerves.

Ročník 2008  Témy časopisu Neurology 2 / 2008

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MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
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prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
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Examples of citations:
1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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Which of following factors is not related to rosacea?
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d. endothelial growth factor

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