Téma:  Case Studies

Subacute cerebellar degeneration as paraneoplastic syndrome – case report and brief review of literature

Daša Viszlayová, Andrea Petrovičová, Marta Miklošková, Tibor Göbö, Gabriel Hajaš, Agáta Frišová, Monika Virágová, Branislav Veselý, Katarína Medovarská, Renáta Felediová

Paraneoplastic (metaneoplastic) neurological syndromes can be defined as clinical neurological syndromes of yet unknown aetiology often preceding a detection of an underlying neoplasm. PNS is a remote effect of cancer on central nervous system which is not directly affected by the primary tumour nor its metastasis. It is believed that PNS are immune-mediated, hence they are associated with immunologic response of organism to the neural antigens expressed by the tumour (resulting to development of onconeuronal antibodies). Paraneoplastic neurological syndromes imply multitude neurological disorders from which paraneoplastic subacute cerebellar degeneration is being one of the most frequent and the best defined. Clinical signs of PCA include paleocerebellar and neocerebellar syndrome. In this case we present a patient with already known oncological disorder, which has been an ovarian carcinoma. The patient was admitted to our hospital due to progression of truncal ataxia, tremor and dysartria. Paraneoplastic cerebellar degeneration (PCD) has been diagnosed on the ground of oncologic history, clinical presentation, positive findings of onconeural antibodies and on imaging techniques results.

Ročník 2008  Témy časopisu Neurology 3 / 2008

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