Téma: Original Works

Association of diabetes mellitus with ischemic stroke

Martin Migra, Vladimír Nosál, Michal Kutlák, Ivana Dedinská, Marián Mokáň, Egon Kurča

Type 2 diabetes mellitus is a severe metabolic disease with increasing incidence and prevalence that is, either as a single disease or the disease with complications, one of the main causes of disablement and high costs for health care in the majority of the countries all over the world. Diabetes is, without any questions, severe risk factor for hypoxemic cerebrovascular accident (CVA) as complication of micro- and macrovascular changes of cerebral arteries and changes of biochemical processes on more levels. The aim of the study was to constitute the incidence of CVA in diabetic patients considering other risk factors (RF) comparing with patients without diabetes, determine the stage of neurological affliction and the length of hospitalization in particular groups of patients. The retrospective study consisted of statistic data from 383 patients hospitalized in the Neurological clinic MFN Martin for ischemic stroke in the years 2004-2006. The basic risk factors were arterial hypertension (AH) and diabetes mellitus (DM). Further risk factors were age, sex, cardioembolisation in ventricular fibrillation, smoking and dyslipidemy. The stage of neurological deficit in patients with hypoxemic CVA was evaluated by NIHS. On basis of all collected data the patients were divided into several groups and data were evaluated statistically. From all selected patients 40 % were treated for diabetes (P < 0.0001), 60 % of patients with further RF for hypoxemic CVA (ventricular fibrillation, arterial hypertension, smoking, dyslipoproteinemy). Results of the study confirm that diabetes mellitus is considerably linked to higher risk of cardiovascular complications, that urges to improve the primary prevention of complications of diabetic disease. Evaluating the stage of neurological deficit and its impact to the length of hospitalization in particular groups of the patients there was no statistical significance in our study, though in diabetics with severe neurological deficit there was the tendency for longer hospitalization. It is inevitable in hospitalized patients to control strictly glycemic levels, as well as antihypertensive and hypolipidemic therapy in acute stage during hospitalization that has the impact to socioeconomic dimensions of hospitalization and further therapy.

Ročník 2009  Témy časopisu Neurology 2 / 2009

CHAIRMAN OF THE EDITORIAL BOARD
doc. MUDr. Miroslav Brozman, CSc.

MEMBERS OF THE EDITORIAL BOARD
MUDr. František Cibulčík, CSc.
doc. MUDr. Eleonóra Klímová, CSc.
doc. MUDr. Pavol Kučera, PhD.
MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
MUDr. Vladimír Nosáľ, PhD.
MUDr. Ľubica Procházková, CSc.
prof. MUDr. Bruno Rudinský, CSc.
doc. MUDr. Daniel Šaňák, Ph.D.
doc. MUDr. David Školoudík, Ph.D., FESO
prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
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3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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