Peter Kružliak1, Martin Brázdik2
Celiac sprue (celiac disease) has lately been an attractive and interesting disease also for its association with neurological diseases. Celiac disease is an inflammatory disease of the small intestine mucous membrane as a result of genetically determined sensitivity to gluten, a component of wheat, barley and rye. Therapy is strict gluten-free diet that results in symptomatic adjustment and recovery of normal architecture of the intestine mucus membrane. Celiac disease can manifest besides classical gastrointestinal symptoms also by an atypical symptomatology. Cook and Smith reported in 1966 for the first time association of celiac disease with neurological diseases. Since a large number of neurological diseases associated with celiac disease have been described, most of all epilepsy, ataxia and neuropathy. Etiopathogenesis and mechanism participating at mentioned association remains unclear.