Téma: Overview works

Cadasil – perspective of a community neurologist

Viera Saly

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopahy) is a hereditary disease of young and middle age adults of various ethnic groups and presents with migraine with aura, transient ischemic attacks, psychiatric disturbances and recurrent strokes leading to subcortical dementia. Prevalence of CADASIL in western Europe is estimated to be approximately 2-4/100 000 while only a few patients have been reported in eastern Europe and other countries. Here, we discuss possible explanations for this discrepancy from the point of view of a community neurologist, including lack of clinical and imaging diagnostic criteria, relative unavailability of genetic tests and usefulness of diagnostic skin biopsy.

Ročník 2010  Témy časopisu Neurology 1 / 2010

CHAIRMAN OF THE EDITORIAL BOARD
doc. MUDr. Miroslav Brozman, CSc.

MEMBERS OF THE EDITORIAL BOARD
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doc. MUDr. Eleonóra Klímová, CSc.
doc. MUDr. Pavol Kučera, PhD.
MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
MUDr. Vladimír Nosáľ, PhD.
MUDr. Ľubica Procházková, CSc.
prof. MUDr. Bruno Rudinský, CSc.
doc. MUDr. Daniel Šaňák, Ph.D.
doc. MUDr. David Školoudík, Ph.D., FESO
prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
Dr. Milan R. Voško, PhD.

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1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Which of following factors is not related to rosacea?
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c. propionibacterium acnes
d. endothelial growth factor

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