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Časopis Neurology – Článok Neurological disorders in vitamin b12 deficiency ‒ a group of 10 patients and review

Neurology

Reviewed, postgraduate scietific medical journal.
Period 3x per year
1336-8621
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Neurology
Neurology
Reviewed, postgraduate scietific medical journal.
Period 3x per year
Predplatné
Téma: Original Works

Neurological disorders in vitamin b12 deficiency ‒ a group of 10 patients and review

Ivan Martinka, Peter Špalek, Viera Hančinová, František Cibulčík, František Jurčaga, Ján Benetin

Vitamin B12 plays an important role in organism as cofactor of important enzymes of intermediary metabolism. Lack of vitamin B12 is caused by malabsorption in the gastrointestinal tract, insufficient nourishment by food or genetic deficiency of methylmalonyl-CoA mutase enzyme. Vitamin B12 deficiency usually presents with various haematological, neurological and psychiatric manifestations. Neurological manifestations include myelopathy, neuropathy and, rarely, optic nerve atrophy. Myelopathy in vitamin B12 deficiency presents as subacute combined degeneration of spinal cord (funicular myelosis), characterised by degeneration of the lateral and posterior columns. We report group of ten patients with deficiency of vitamin B12 and various neurological symptoms. In three patients the diagnosis of funicular myelosis was done, in 2 of them in combination with polyneuropathy. 6 patients had clinical and electrophysiological symptoms or signs characteristic for polyneuropatia. One patient had sexual dysfunction and problems with memory in combination with polyneuropathy. All of the patients were treated with intramuscular injections of cobalamin, the symptoms and signs have improved fully or at least partially.

vitamin B12 deficiency, subacute combined degeneration of spinal cord, polyneuropathy, life-long substitution of vitamin B12
Neurológia 2012; 7 (3): 131-137

Ročník 2012  Témy časopisu Neurology 3 / 2012

Overview works

Branislav Kollár, Petra Keményová, Pavel Šiarnik, Lucia Krížová, Zuzana Čarnická, Zoltán Goldenberg, Katarína Klobučníková
František Cibulčík
Stanislav Šutovský1, Andrej Blaho1, Branislav Kollár1, Pavol Šiarnik1, Jozef Dragašek2, Ľubomíra Izáková3, Peter Turčáni1

Original Works

Ivan Martinka, Peter Špalek, Viera Hančinová, František Cibulčík, František Jurčaga, Ján Benetin
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CHAIRMAN OF THE EDITORIAL BOARD
doc. MUDr. Miroslav Brozman, CSc.

MEMBERS OF THE EDITORIAL BOARD
MUDr. František Cibulčík, CSc.
doc. MUDr. Eleonóra Klímová, CSc.
doc. MUDr. Pavol Kučera, PhD.
MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
MUDr. Vladimír Nosáľ, PhD.
MUDr. Ľubica Procházková, CSc.
prof. MUDr. Bruno Rudinský, CSc.
doc. MUDr. Daniel Šaňák, Ph.D.
doc. MUDr. David Školoudík, Ph.D., FESO
prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
Dr. Milan R. Voško, PhD.

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Examples of citations:
1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Which of following factors is not related to rosacea?
a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

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Send contributions in the e-mail to the address: stachova@amedi.sk
Period 3x per year
1336-8621
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Neurology
Neurology
Reviewed, postgraduate scietific medical journal.
Period 3x per year
Predplatné