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Časopis Neurology – Článok The nutritional factors affecting epigenetic regulation in the multiple sclerosis pathogenesis

Neurology

Reviewed, postgraduate scietific medical journal.
Period 3x per year
1336-8621
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Neurology
Neurology
Reviewed, postgraduate scietific medical journal.
Period 3x per year
Predplatné
Téma: OVERVIEW WORKS

The nutritional factors affecting epigenetic regulation in the multiple sclerosis pathogenesis

Martin Samohýl, Ľubomír Lisý, Roman Rams, Katarína Hirošová, Diana Vondrová, Daniela Krajčová, Alexandra Filová, Jana Jurkovičová

Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS), characterized by demyelination
and axonal degeneration. Epigenetics is defined as genetic change, which does not occur due to changes
in the DNA sequence. Epigenetics, or changes in genes expression may have a greater impact on the development and
progression of SM than a mutation at a particular locus. Nutritional deficits in childhood may constitute a transgenerational
responses and transgenerational genetic defects. It is believed that MS may have epigenetic origin. Epigenetic
modified genes as the consequences of nutritional factors are related to neurodegeneration. Studies of human neuroblastoma
cells showed epigenetic changes resulting in increased production of beta peptide as a consequence of reduced
vitamin B intake. Coenzyme Q10 has the positive effect on the MS treatment, patients had significantly reduced the
malondialdehyde (MDA) levels. Vitamin A 25,000 IU/day reduces the myelin oligodendrocyte glycoprotein (MOG) levels
induced by T cells proliferation. MS patients, who take calcium in dosage 1,200 mg/day and vitamin D3 in the range
from 28,000 to 280,000 IU/once a week, had reduced T cells reactivity and relapses reduction. Multiple sclerosis is often
associated with vitamin B12 deficiency. It demonstrates the significant relationship with heredity algorithm. Haplotypes
containing the major histocompatibility complex DR beta 1 (HLA-DRB1)*15 have predictive value for genetic
risk. Epigenetic changes are likely to be involved in the process of oligodendrocytes damage in the MS pathogenesis.

nutritional factors, epigenetics, multiple sclerosis
Neurológia 2015; 10 (2): 69-73

Ročník 2015  Témy časopisu Neurology 2 / 2015

OVERVIEW WORKS

Daša Viszlayová, Miroslav Brozman
Ľubomír Lisý
Martin Samohýl, Ľubomír Lisý, Roman Rams, Katarína Hirošová, Diana Vondrová, Daniela Krajčová, Alexandra Filová, Jana Jurkovičová
Pavel Šiarnik, Zuzana Čarnická, Andrej Blaho, Stanislav Šutovský, Katarína Klobučníková, Branislav Kollár, Peter Turčáni

ORIGINAL WORKS

Peter Špalek, Jozef Lukáč, Iveta Mečiarová
Andrej Blaho, Stanislav Šutovský, Pavel Šiarnik, Petra Kemenyová, Peter Turčáni

Michal Minár, Peter Valkovič
Martin Hrubiško

CASE STUDIES

Melišek Martin, Rudinský Bruno, Kurinec František
Žingor Daniel, Rudinský Bruno
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Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
doc. MUDr. Miroslav Brozman, CSc.

MEMBERS OF THE EDITORIAL BOARD
MUDr. František Cibulčík, CSc.
doc. MUDr. Eleonóra Klímová, CSc.
doc. MUDr. Pavol Kučera, PhD.
MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
MUDr. Vladimír Nosáľ, PhD.
MUDr. Ľubica Procházková, CSc.
prof. MUDr. Bruno Rudinský, CSc.
doc. MUDr. Daniel Šaňák, Ph.D.
doc. MUDr. David Školoudík, Ph.D., FESO
prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
Dr. Milan R. Voško, PhD.

EDITOR-IN-CHIEF
Eva Stachová
e-mail: stachova@amedi.sk

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PROOFREADING OF ENGLISH TEXTS
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SECTIONS

OVERVIEW PAPERS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy. Maximum size is 7 pages (font size 12, line spacing 1.5) with maximum 6 pictures (graphs). In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office. Write the article with emphasis on its practical usage for neurologists.

CASE STUDY
Maximum extent is 7 pages. Structuring: summary, introduction, case study, discussion, conclusion, bibliography.

DIAGNOSTIC AND THERAPEUTICAL ALGORITHMS
Diagnosis and therapy processed into tables and schemes, with minimum text, with emphasis on conciseness and clarity.

MISCELLANEOUS
Reaction to overview articles, news in the field of diagnostics, therapy, trial results (maximum 3 pages), reports from professional events, abstracts from scientific work published abroad, not older than 1 year. Maximum extent is 1 page. Write the title of the paper in Slovak/Czech, authors, workplace, then title of the paper in English with full citation.

APPENDIX - GENERAL MEDICINE
Intersectional theme elaborated complexly, well-arranged, clear (extent up to 12 pages).


MANUSCRIPT ELABORATION

Write the paper on computer in any common text editor.
- write full length of lines (do not use ENTER at the end of a line)
- - do not arrange text into columns
- - do not do page make-up, put tables at the end of the paper
- distinguish precisely numbers 1, 0 and letters l, O
- use always parentheses ( )
- explain abbreviations always when first used


MANUSCRIPT REQUIREMENTS

1. An accurate paper title, names and surnames of all authors including titles, authors` workplace. The first author address including the phone number, fax and e-mail address.
2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies and Appendices - General Medicine). Write in 1st or 3rd person singular or plural (unify according the type of an article).
3. Key words - in the extent of 3-6 (only for overview papers and Appendices - General Medicine).
4. English translation: paper title, summary, key words (only at overview papers, and Appendices - General Medicine)
5. Text
If you insert pictures into a document, send also their original files in "jpg" format, create graphs in Excel and send also their original files. If you send photo documentation via post office, please, send just high-class originals. Mark each original by a number, under which it is mentioned in the text. Write in 1st or 3rd person singular or plural (unify according the type of an article).
6. Bibliography
Citations are numbered chronologically in bold, references in the text are stated by the number of citations in parentheses. Use maximum 20 citations.

Examples of citations:
1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

Do not use dots after first names in citations. Do not use colon but dot after names of authors. Use semi-colon after the year of publishing, colon is before pages. If an author is one, two or three - it is necessary to state all. If there are more than three authors it is necessary to write first three and "et all".

Due to publishing of autodidactic tests it is necessary to add 4 questions to your article and 4 answers with marking of one correct answer, e.g.:

Which of following factors is not related to rosacea?
a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

All published papers are paid.

Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-patient neurological practice.

Send contributions in the e-mail to the address: stachova@amedi.sk
Period 3x per year
1336-8621
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Neurology
Neurology
Reviewed, postgraduate scietific medical journal.
Period 3x per year
Predplatné