Slavomíra Kováčová
Multiple sclerosis ( MS ) is chronic autoimmune inflammatory and degenerative disorder of the central nervous system
with probably multifactorial etiology which mostly affect young people around age of 30. The most frequent form is relapse
remittent form which preferentially affects females with clinical onset often during child bearing years. So there
are many questions about disease impact on reproduction, gravidity and babies’ health as well. Fertility does not seem
to be impaired to a larger extent in women with MS. During pregnancy hormonal changes have beneficial effect for
disease activity suppression. SM does not increase the risk of complication during gravidity and there is also no negative
effect on foetus and new-born provided there is an absence of other relevant problems. The most risky period for
reactivation of MS activity is during first 3 to 6 months after en_delivery. The strongest predictor of postpartum relapses
seems to be higher annual relapse rate prior to conception and during gravidity as well as higher grade of disability in
the beginning course of disease.