Boris Rychlý, Magdaléna Puchertová, Marián Švajdler
Previous WHO classifications of tumors of the central nervou system were histogenetic, diagnostic entities were defined
only by histomorphology. In the last classification it is for the first time that molecular genetic markers are directly
incorporated into the definition of several diagnostic entities. This so-called integrated diagnosis links both the histologic
and genetic features for the diagnosis of several tumors. New entities that are defined by histology and molecular
features are IDH-wild-type and IDH-mutant glioblastoma, H3 K27M–mutant diffuse midline glioma, RELA fusion–positive
ependymoma, WNT-activated and SHH-activated medulloblastoma and C19MC-altered embryonal tumor with
multilayered rosettes. Last WHO classification from 2016 should be for the brain tumor diagnostics mandatory.