Téma: 

Relation between genetic glutation – s-transferase polymorphisms and prostate carcinoma

Monika Sivoňová, Tatiana Matáková, Dušan Dobrota, Ján Kliment jr

Prostate carcinoma is the third commonest solid tumor in males over 50 in Slovakia. Genetic predisposition, dietary factors, life style as well as environmental conditions may influence the risk of development of prostate carcinoma. Metabolizing of a large group of xenobiotics, that can under special conditions work as strong mutagens or carcinogens, needs biotransformation enzymatic system. An important role in the phase II of biotransformation belongs to enzymes of glutation – S-transferase (GST) that catalyze conjugation of activated xenobiotics with glutation and thus guarantee its excretion to urine or bile. Polymorphisms of genes for GST are linked with change of enzyme activity of GST that results in decreasing of detoxification ability and change of individual susceptibility to prostate carcinoma.

Ročník 2006  Témy časopisu Clinical urology 3 / 2006

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