Téma: 

Combination therapy of alpha-blocker and tolterodin er in patients with benign prostatic obstruction and overactive bladder

1Ján Švihra, 2Ivana Zigová, 3Ján Šebo, 4Ondrej Hajdúk, 5Peter Piovarči

Objective: The objective of this study was to assess the efficacy and tolerability of tolterodine ER in combination with any alphablocker in the treatment of the benign prostatic obstruction and overactive bladder (OAB). Materials and methods: This study was a prospective, non-interventional drug monitoring program in the context of which subjects received treatment with tolterodine ER while they continued to take their alpha1-blockers. When a patient was enrolled in the study for his pathological condition, then all the demographic data, indication diagnosis, previous therapy as well as other previous and concomitant medication and general history were recorded. At the final examination the number of frequency, urgency, nocturia, urge incontinence and acute urinary retention episodes with regard to the efficacy of tolterodine ER was recorded. Results: 495 patients with benign prostatic obstruction and overactive bladder were enrolled, 478 (96.6 %) subjects completed the study treatment. The majority of clinicians or patients rated the study medication as excellent (299/492; 60.8 % or 336/492; 68.3 %). The number of frequency episodes per 24 hours decreased from the mean baseline value of 12.72 to 8.16 at final visit. The number of incontinence episodes per 24 hours decreased from the mean baseline value of 2.02 to 0.64 at final visit. The number of nocturia episodes decreased from the mean baseline value of 3.73 to 1.35 at final visit. There were no deaths or serious adverse events in this study. Conclusion: At the final visit a decrease in the mean number of episodes of all OAB symptoms was observed. The majority of clinicians and patients rated the treatment as excellent. Treatment with tolterodine ER was generally well-tolerated.

Ročník 2009  Témy časopisu Clinical urology 1 / 2009

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