Téma: 

Urgencymetry 1.0 – quantification of urgency in females with overactive bladder

Ján Švihra1, Ján Ľupták1, Peter Zvara2, Rudolf Husár3, Ján Kliment1

Objective: Overactive bladder (OAB) is urgency, with or without urge incontinence, usually with frequency and nocturia. Urgency is defined as the complaint of a sudden compelling desire to pass urine which is difficult to defer. The urinary urgency as the most clinically significant symptom of the overactive bladder requires quantification. The aim of this study was to assess reliability of a new diagnostic tool the Urgencymetry 1.0 for the urinary urgency in females. Methods: Patients with OAB were interviewed face-to-face about visual analogue scale (VAS) as a possible instrument for measurement of urinary urgency. The Urgencymetry 1.0 was constructed as an urgencymetric disc divided into 24-hour lines according to the VAS 0-100 (0 represents no urgency, 100 represents the most extreme urgency). Subjects used correct points on the VAS during the actual time. The Urgencymetry 1.0 was assessed in the prospective study of untreated females with urgency (study group) and without urgency (control group) and in solifenacin treated females with urgency (treatment group). Analysis quantified stage of urgencies (VAS) and urgency episodes (UE) during 24-hour period. Treatment group was used for urgencymetric test-retest and responsiveness to changes. All females filled validated version of the 33-item OAB questionnaire (OABq) for assessment of the impact of OAB symptoms on health related quality of life (symptom bother score and HRQL scale). Statistical nonparametric tests were used for statistical analyses, p < 0.05 was statistically significant. Results: A total of 366 urgencymetric discs were collected from 122 females (61 females – study group, 40 females – control group, 21 females – treatment group). Mean age of 48 years (range 20-74 years), mean Symptom bother score of 31.9 (r. 0.0-80.0), total HRQL score of 74.6 (r. 20.0-100.0), Urgency VAS of 27.9 (r. 0-78) and mean number UE per 24-hour period reached of 9.4 (r. 0-24). Spearman correlations among OABq scores and urgencymetric values confirmed statistically significant relations in study, control and treatment groups. The subjects of study group had statistically significant higher mean Symptom bother score vs. control group (44.9 ± 18.8 vs. 1.2 ± 2.8; p < 0.01), mean HRQL total score (64.1 ± 16.7 vs. 99.0 ± 2.7; p < 0.01), mean Urgency VAS (42.7 ± 16.2 vs. 2.2 ± 4.7; p < 0.01) and mean Urgency episodes per 24-hour period (14.1 ± 4.1 vs. 0.3 ± 0.5; p < 0.01). Values for the Cronbach’s alpha measure of internal consistency as a function of days of recording were of 0.88 vs. 0.92 (two days VAS vs. three days VAS) and of 0.80 vs. 0.81 (two days UE vs. three days UE). For test-retest reliability Spearman’s correlation coefficient was of 0.78 (p < 0.01). There were statistically significant differences in responses to solifenacin in treatment group (baseline VAS of 41.4 ± 11.8, final VAS of 23.0 ± 9.6). Conclusion: Urgencymetric values confirmed good correlation between 33-item OAB questionnaire (OABq) for assessment of the impact of OAB symptoms on health related quality of life, good internal consistency and reliability, good responsiveness to treatment.

Ročník 2009  Témy časopisu Clinical urology 3 / 2009

CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ján Kliment, CSc.

MEMBERS OF THE EDITORIAL BOARD
prof. Andrzej Borówka, M.D., PhD.
prof. MUDr. Ján Breza, DrSc.
prof. MUDr. Peter Bujdák, PhD.
prof. MUDr. Tomáš Hanuš, DrSc.
doc. MUDr. Ladislav Jarolím, CSc.
doc. MUDr. Ján Ľupták, PhD.
doc. MUDr. Jozef Marenčák, PhD.
doc. MUDr. Ivan Minčík, PhD.
prof. MUDr. Dalibor Ondruš, DrSc.
prof. Imre Romics, M.D., PhD.
doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
prof. MUDr. Ladislav Valanský, PhD.
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MUDr. Peter Zvara, PhD.

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