Téma: Overview works

Svetlobunkového karcinómu obličky

Hana Garanová, Igor Andrašina, Andrea Cipková

Advances in understanding biology and genetics of renal cell carcinoma (RCC) have led to novel targeted approaches for the treatment of metastatic RCC (mRCC). Discovery of a relationship for the VHL (von Hippel-Lindau) suppressor gene, hypoxia inducible factor-1 alpha, and vascular endothelial growth factor in the pathogenesis, has identified a pathway for targeted therapy. Angiogenesis is known to play a critical role in the growth of tumours and is an important target for the development of novel anticancer therapies (VEGF, mTOR). Temsirolimus is a selective inhibitor of mTOR (mammalian target of rapamycin). Temsirolimus binds to an intracellular protein FKBP-12, and the protein/temsirolimus complex binds and inhibits the activity of mTOR that control cell division. Temsirolimus selectively impairs the translation of cell cycle regulatory proteins and has antiangiogenic effects. Temsirolimus and everolimus, rapamycin analogues have recently been tested in phase IIII trials in the first and second line treatment in patients with advanced metastatic clear cell renal cell carcinoma. Temsirolimus is indicated for the first-line treatment of patients with advanced renal cell carcinoma who have at least three of six prognostic risk factors. Everolimus is indicated for the second line treatment of patients with advanced renal cell carcinoma whose disease had progressed on treatment with VEGF receptor tyrosine kinase inhibitors.

Ročník 2010  Témy časopisu Clinical urology 2 / 2010

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prof. MUDr. Ján Kliment, CSc.

MEMBERS OF THE EDITORIAL BOARD
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prof. MUDr. Ján Breza, DrSc.
prof. MUDr. Peter Bujdák, PhD.
prof. MUDr. Tomáš Hanuš, DrSc.
doc. MUDr. Ladislav Jarolím, CSc.
doc. MUDr. Ján Ľupták, PhD.
doc. MUDr. Jozef Marenčák, PhD.
doc. MUDr. Ivan Minčík, PhD.
prof. MUDr. Dalibor Ondruš, DrSc.
prof. Imre Romics, M.D., PhD.
doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
prof. MUDr. Ladislav Valanský, PhD.
doc. MUDr. František Záťura, PhD.
MUDr. Peter Zvara, PhD.

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prof. MUDr. Ján Švihra, PhD.

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The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy. Maximum extent is 7 pages of text (font ARIAL or TIMES, font size 12, line spacing 1.5). In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office.

ORIGINAL PAPERS
Structuring: introduction, clinical group and methods, results, discussion, conclusion, bibliography

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CASE STUDY
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2. Summary - structured abstract: goal of work, material and methods (do not state the name of the workplace), results, conclusion
3. Key words - in the extent of 3-6.
Write in 1st or 3rd person singular or plural (unify according the type of an article).
4. English translation: the title of the paper, summary, key words 5. Text
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Citation means in general: the surname of the author (authors), title of the work, year of issuing, volume, pages.
Do not use "ét al.", but state all authors.

Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285: 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981:15-27.

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The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

Which of following factors is not related to rosacea?
a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

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