Téma: 

Prevalence of testosterone deficiency syndrome in men 40 to 69 years of age in slovakia

Igor Sopilko, Ján Švihra, Ján Kliment

Aims of study: Androgen deficiency in the elderly male is considered a syndrome that is characterized by the presence of defined signs/symptoms in conjunction with low testosterone levels. The objective of this study was to examine the association between symptoms of androgen deficiency and low total and calculated free testosterone levels and estimate the prevalence of symptomatic androgen deficiency in aging men in Slovakia. Materials and methods: From October, 2009 to February, 2010 a total of 157 men from the region of Martin, between the ages of 40 to 72 years with complete data on testosterone, other hormones and symptoms of androgen deficiency were randomly selected with the cooperation of general practitioners. Outcomes were measured as symptomatic androgen deficiency, defined as low total (< 10.4 nmol/l) and free (< 0.17 nmol/l) testosterone plus presence of low libido, erectile dysfunction, or two or more of following symptoms: sleep disturbance, depressed mood, lethargy, or diminished physical performance. All subjects participating in the study filled a Slovak version of two questionnaires: Aging Male’s Symptoms Rating Scale (AMS) and International Index of Erectile Function (IIEF). Results: Mean age of the sample was 54.6 ± 9.2 years. The sample was mostly married or living with a partner (85.4 %). Mean total and free testosterone was 15.79 ± 5,76 nmol/l and 0.286 ± 0.103 nmol/l, respectively, and mean SHBG was 40.23 ± 16.73 nmol/l. Approximately 17 % of subjects had total testosterone less than 10.4 nmol/l and 8 % of subjects calculated free testosterone less than 0.17 nmol/l. A total of 12 men (7.6 %) met the criteria for symptomatic androgen deficiency. The crude prevalence of symptomatic androgen deficiency was 7.48 % (95 % confidence interval: 3.23-11.73 %) in the group of men from the ages of 40 to 69 years. The prevalence increased markedly with age. Age-specific prevalence of the age groups in the region of Martin was: 40-49 years (1.75 %), 50-59 years (7.04 %) and 60-69 years (18.38 %). Using method of population projection comparable estimated prevalence of the same age groups in Slovakia was established. Conclusion: To our knowledge, this is the first epidemiologic study in Slovakia to present prevalence data on androgen deficiency using a definition that incorporates both signs/symptoms and testosterone levels. We demonstrated that the crude prevalence of testosterone deficiency syndrome in men with the age group of 40 to 69 years is approximately 7.5 %. Projection of age-specific prevalence with symptomatic androgen deficiency we estimated that there are 1300 men in the region of Martin and 72 000 men in the Slovak republic. Our study describes the prevalence of androgen deficiency in the aging male population, showing a clear, and substantially increases of androgen deficiency with age.

Ročník 2010  Témy časopisu Clinical urology 2 / 2010

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