Téma: 

Expression changes of caveolin 1 in oncogenesis of renal cell carcinoma

Lucia Mésarošová 1, Ján Švihra 2, Ján Klimas 3, Peter Křenek 3, Ján Kyselovič 3, Peter Ochodnický 3, Ján Ľupták 2, Ján Kliment 2, Pavol Slávik 4

Introduction and objectives: Renal cell carcinoma is the most common malignant disease of the kidney. It accounts for 3 % of all adult malignancies. The 20-30 % of patients are often diagnosed with metastatic disease. Material and methods: Samples of tumor and healthy tissues obtained from patients by radical nephrectomy were used to determine the expression of Cav-1 by western blot and immunohistochemistry. Changes of the expression level were correlated with TNM classification and Fuhrman nuclear grading of the tumors. Patients were divided into groups according to TNM classification and Fuhrman´s grading. Results: We observed over-expression of Cav-1 in the stages T1a of TNM and G1 of Fuhrman´s grading. Conclusion: Cav-1 may participate in the growth of tumors cell and angiogenesis and could be used as a biomarker of renal cell carcinoma.

Ročník 2010  Témy časopisu Clinical urology 3 / 2010

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