Ivan Kron1, Patrik Jalč1, Ladislav Valanský2, Vincent Nagy2, Ľubomír Lachváč2, Ivan Andrašina3
Aim: to evaluate changes in excretion of amino acids and their metabolites in the urine before and after nephrectomy in patients with renal cell carcinoma (RCC). Material and methods: 34 patients (mean age 58 y.) with RCC without metastases and 43 healthy volunteers (mean age 40 y.) were examined for pH, amino acids, urea, uric acid, ammonia and creatinine in the first morning urine, in patients before and 7 days after nephrectomy. Results: The most significant changes were recorded for glycine and serine, which levels were decreased in the first morning urine before nephrectomy in comparison to controls. After nephrectomy their levels reached the levels of healthy volunteers. Conclusions: Decreased levels of glycine and serine proved to be the best indicators of RCC present in patients because after neproctomy their levels were normalized.