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Časopis Clinical urology – Článok Outcomes of radical prostatectomy in men with high-risk prostate cancer

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné
Téma: 

Outcomes of radical prostatectomy in men with high-risk prostate cancer

Ján Kliment ml., Boris Eliáš, Ján Ľupták, Ján Švihra, Karol Kajo1, Kamil Javorka, Igor Sopilko, Martin Jonáš, Ján Kliment st.

Objective: To assess pathological findings and oncological outcomes after radical prostatectomy in men with high-risk prostate cancer Materials and methods: We performed retrospective analysis of 151 prostate cancer patients who underwent open retropubic radical prostatectomy for high-risk prostate cancer between 1995 and 2009. High-risk prostate cancer was defined according to the D´Amico classification: ≥ T2c or Gleason score ≥ 8 or PSA ≥ 20 ng/ml. Time to biochemical progression, specific and overall survival curves were constructed by the Kaplan-Meier method and long-rank tests were used for comparison of the survival curves. Results: Mean age of patients was 62.1 ± 5.7 years (range 48-76), median 63 years. The mean follow up was 53 months (range 9-163), median 40. The mean pre-operative PSA was 16.3 ± 13.0 ng/ml (range 2.5-100), median 13.5 ng/ml. In the clinical stage 11 (7.3 %) patients had cT1c, 21 (13.9 %) had cT2 and 119 (78.8 %) had cT3 prostate cancer. In the pathological stage, 3 (2.0 %) patients had pT2a, 3 (2.0 %) had pT2b, 38 (25.2 %) had pT2c, 34 (22.5 %) had pT3a, 71 (47 %) had pT3b and 2 (1.3 %) had pT4 prostate cancer. Biopsy Gleason score ≤ 6 had 66 (43.7 %) patients, Gleason score 7 had 41 (27.2 %), Gleason score 8 had 31 (20.5 %) and Gleason score 9 had 13 (8.6 %) patients. For the pathological specimen, 27 (17.9 %) patients had Gleason score ≤ 6, 80 (52.9 %) had Gleason score 7, 18 (11.9) had Gleason score 8 and 26 (17.2 %) patients had Gleason score 9. Positive surgical margins had 64 (42.4 %) patients and 11 (7.3 %) patients had positive lymph nodes. The 3, 5, 10 – years biochemical recurrence – free survival rate was 85.92 %, 65.78 % and 27.27 %, respectively, cancer-specific survival was 97.59 %, 94.09 % and 67.89 %, respectively, overall survival was 94.9%, 91.5% and 66.02 %, respectively. The strongest predictor of biochemical progression was the pathological stage, positive surgical margin and Gleason score. The favourable pathology defined by ≤ pT2c, pN0, Gleason score ≤ 7 and negative surgical margin had 36 patients (23.8 %). Conclusions: Radical prostatectomy for high-risk prostate cancer may produce acceptable oncological control of the disease and for selective group of patients can be sufficient. However, for some patients radical prostatectomy may be part of a multimodal treatment including adjuvant radiotherapy or hormonal treatment.

high-risk prostate cancer, radical prostatectomy, multimodal treatment
Klin. urol. 2011; 7 (2-3): 57-63

Ročník 2011  Témy časopisu Clinical urology 2 / 2011

Martina Ondrušová1, Ján Kliment2, Dalibor Ondruš3
Ján Kliment ml., Boris Eliáš, Ján Ľupták, Ján Švihra, Karol Kajo1, Kamil Javorka, Igor Sopilko, Martin Jonáš, Ján Kliment st.
Ondřej Havránek1, Jan Krhut1, Jaroslav Hájek2, Jozef Kopecký1, David Feltl2
Martin Fabišovský1, Henryk Fikoczek2, Jana Dvořáčková3, Jan Krhut1

Overview works

David Míka, Jan Krhut
Ján Kliment

Case Studies

Ľubomír Lachváč, Ľubomír Špak*, Ladislav Valanský, Vincent Nagy
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Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ján Kliment, CSc.

MEMBERS OF THE EDITORIAL BOARD
prof. Andrzej Borówka, M.D., PhD.
prof. MUDr. Ján Breza, DrSc.
prof. MUDr. Peter Bujdák, PhD.
prof. MUDr. Tomáš Hanuš, DrSc.
doc. MUDr. Ladislav Jarolím, CSc.
doc. MUDr. Ján Ľupták, PhD.
doc. MUDr. Jozef Marenčák, PhD.
doc. MUDr. Ivan Minčík, PhD.
prof. MUDr. Dalibor Ondruš, DrSc.
prof. Imre Romics, M.D., PhD.
doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
prof. MUDr. Ladislav Valanský, PhD.
doc. MUDr. František Záťura, PhD.
MUDr. Peter Zvara, PhD.

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prof. MUDr. Ján Švihra, PhD.

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The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy. Maximum extent is 7 pages of text (font ARIAL or TIMES, font size 12, line spacing 1.5). In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office.

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Citations are numbered chronologically in bold, references in the text are stated by the number of citations in parentheses.
Citation means in general: the surname of the author (authors), title of the work, year of issuing, volume, pages.
Do not use "ét al.", but state all authors.

Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285: 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Which of following factors is not related to rosacea?
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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

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Send contributions in the e-mail to the address: paulenova@amedi.sk
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné