Silvia Mahmood1, Monika Kmeťová-Sivoňová1, Dušan Dobrota1, Marta Pisková1, Róbert Dušenka1,2, Svetlana Grobarčíková2 a Ján Kliment2
The prostate gland is abundant in peptide growth factors which play an important role in intracellular processes such as cell growth, differentiation, angiogenesis and apoptosis. They also contribute significantly to the malignant transformation during carcinogenesis process. The most common prostate disease is prostate cancer (CaP) that mainly affects men in old age. The aim of this review is to summarize the current knowledge about the role of VEGF and its receptors in the development of prostate cancer as well as monitoring of potential prognostic and predictive role of gene polymorphisms of VEGF in patients with prostate cancer.