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Časopis Clinical urology – Článok Tumor necrosis as a histomorphological prognostic parameter in clear cell renal carcinoma

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné
Téma: 

Tumor necrosis as a histomorphological prognostic parameter in clear cell renal carcinoma

Vladimír Bartoš1, Oľga Zacharová1, Dušan Pokorný1, Roman Mráz2, Juraj Mikuláš2, Peter Laurinc2

Background: Renal cell carcinoma (RCC) quite frequently exhibits necrotic changes that probably represent an important histological prognostic parameter. Aim: The purpose of this study was to assess the prevalence and the extent of tumour necroses in the set of conventional clear cell RCCs and to evaluate their relationship with other basic clinico-pathological parameters. Material and methods: We retrospectively evaluated representative cases of histologically verified clear cell RCCs, which had been diagnosed at the Department of Pathological Anatomy in Faculty Hospital in Zilina from January 2010 to March 2012. A complete study group consisted of 100 cancers from 100 patients (64 men, 36 women), who were divided into group A (without necroses), and group B (with necroses). Results: Necrotic changes were present in 39 % of all cases assessed. In this group, we more frequently found a male gender, lower degree of differentiation (grading), larger average size of lesions, common sarcomatoid changes, and more advanced stage of disease in comparison with group without tumour necroses. In addition, all cases with proven regional lymph node metastases occurred only in group B. Conclusion: In our study, we showed frequent necrotic changes in clear cell RCCs. Although it would be necessary to provide a long-term follow-up of the patients and clinical outcome of the disease for definite determination of their prognostic significance, based on our results we can confirm that RCCs with necroses are associated with other unfavourable histopathological parameters and thus they indicate a worse prognosis.

renal cell carcinoma, necroses, prognosis
Klin. urol. 2012; 8 (1): 34-37

Ročník 2012  Témy časopisu Clinical urology 1 / 2012

Overview works

Martina Ondrušová1,2, Dalibor Ondruš3
Dalibor Pacík
Roman Tomaškin, Boris Eliáš, Ján Kliment
Silvia Mahmood1, Monika Kmeťová-Sivoňová1, Dušan Dobrota1, Marta Pisková1, Róbert Dušenka1,2, Svetlana Grobarčíková2 a Ján Kliment2

Vladimír Bartoš1, Oľga Zacharová1, Dušan Pokorný1, Roman Mráz2, Juraj Mikuláš2, Peter Laurinc2

Ján Švihra1, Ivana Zigová2, Milan Švec3, Eva Šulcová4

Monika Kmeťová Sivoňova1, Marta Pisková1, Dušan Dobrota1, Róbert Dušenka1,2, Svetlana Grobarčíková2, Silvia Mahmood1, Ján Kliment2
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CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ján Kliment, CSc.

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prof. MUDr. Ján Breza, DrSc.
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doc. MUDr. Ladislav Jarolím, CSc.
doc. MUDr. Ján Ľupták, PhD.
doc. MUDr. Jozef Marenčák, PhD.
doc. MUDr. Ivan Minčík, PhD.
prof. MUDr. Dalibor Ondruš, DrSc.
prof. Imre Romics, M.D., PhD.
doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
prof. MUDr. Ladislav Valanský, PhD.
doc. MUDr. František Záťura, PhD.
MUDr. Peter Zvara, PhD.

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Which of following factors is not related to rosacea?
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Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné