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Časopis Clinical urology – Článok Nat2 genetic polymorphism and prostate cancer risk: a pilot study in the slovak population

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné
Téma: 

Nat2 genetic polymorphism and prostate cancer risk: a pilot study in the slovak population

Monika Kmeťová Sivoňova1, Marta Pisková1, Dušan Dobrota1, Róbert Dušenka1,2, Svetlana Grobarčíková2, Silvia Mahmood1, Ján Kliment2

Introduction and Aims: The N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum of naturally occurring xenobiotics including carcinogens and drugs. Variation at the NAT2 gene has been linked to the human acetylation capacity, either “slow” or “fast”, which modifies susceptibility to cancer and adverse drug reactions. The aim of our pilot study was to investigate whether NAT2 genotypes/phenotypes are associated with increased risk factor for prostate cancer in the Slovak population and to study the clinico-pathological correlations and the prognostic significance of NAT2. Material and Methods: We genotyped four common single nucleotide polymorphisms (SNPs) in NAT2 among 179 prostate cancer patients and 269 healthy controls by using PCR-RFLP (polymerase chain reaction restriction fragment length polymorphism analysis). Relative risk of prostate cancer for NAT2 genotypes/NAT2 acetylation phenotypes was estimated using chi squared method. Results: We observed no significant association between NAT2 genotypes/phenotypes and prostate cancer risk. We have found that rapid acetylators have significantly higher serum PSA levels than slow acetylators (p < 0.05), indicating increase generation of carcinogens and enhance tumourogenesis. Conclusions: Data of our pilot study demonstrate that the NAT2 polymorphism is not associated with the risk of developing prostate cancer in the Slovak population. Future studies concerning the association of NAT2 genotypes and environmental/lifestyle factors will be important to elucidate the real meaning of NAT2 polymorphisms in the susceptibility to prostate cancer.

N-acetyltransferase 2, gene polymorphism, prostate cancer
Klin. urol. 2012; 8 (1): 44-48

Ročník 2012  Témy časopisu Clinical urology 1 / 2012

Overview works

Martina Ondrušová1,2, Dalibor Ondruš3
Dalibor Pacík
Roman Tomaškin, Boris Eliáš, Ján Kliment
Silvia Mahmood1, Monika Kmeťová-Sivoňová1, Dušan Dobrota1, Marta Pisková1, Róbert Dušenka1,2, Svetlana Grobarčíková2 a Ján Kliment2

Vladimír Bartoš1, Oľga Zacharová1, Dušan Pokorný1, Roman Mráz2, Juraj Mikuláš2, Peter Laurinc2

Ján Švihra1, Ivana Zigová2, Milan Švec3, Eva Šulcová4

Monika Kmeťová Sivoňova1, Marta Pisková1, Dušan Dobrota1, Róbert Dušenka1,2, Svetlana Grobarčíková2, Silvia Mahmood1, Ján Kliment2
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prof. MUDr. Dalibor Ondruš, DrSc.
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prof. MUDr. Ján Švihra, PhD.
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Which of following factors is not related to rosacea?
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Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné