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Časopis Clinical urology – Článok Oxidative damage to dna and prostate cancer

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné
Téma: 

Oxidative damage to dna and prostate cancer

Monika Kmeťová - Sivoňová1, Ľubica Stankovičová1, Marta Vilčková1, Dušan Dobrota1, Mária Kovalská1, Zuzana Tatarková1, Martina Pavlíková1, Ján Kliment2

Introduction and Aims: Reactive oxygen species (ROS) mediated DNA damage in addition to ineffective DNA repair mechanisms are well established lesions common to human cancers. DNA alterations like strand breaks, base modifications and DNA-protein cross linkages are all strongly implicated in the initiation stage of carcinogenesis. Major oxidative DNA damage product 8-oxo-7,8-dihydro-2´-deoxyguanosine (8-oxodG) is regarded as a potential biomarker of mutagenesis consequent to oxidative stress. The aim of the present study was to detect the DNA oxidative damage in prostate cancer and in healthy individuals to understand the mechanism, to monitor participation of the oxidative stress in the process of damage of biologically important molecules and in the process of carcinogenesis. Material and Methods: The study included 20 prostate cancer patients (mean ± SEM: 63.35 ± 1.8 years) and 20 control subjects (mean ± SEM: 65.95 ± 1.8 years) for the analysis of 8-oxodG using a modified single cell gel electrophoresis (Comet assay). The results were analysed with the Student’s paired t-test. Results: The levels of 8-oxodG were significantly higher (p < 0.05) in prostate cancer patients than in controls. There was a positive correlation between the levels of 8-oxodG and serum PSA levels and we have found no correlation between 8-oxodG and Gleason score in prostate cancer patients. Conclusions: Our results demonstrate that an increased rate of oxidative stress might play a role in the pathogenesis of prostate cancer as evidenced by a failure in the oxidant/antioxidant balance in favour of DNA damage.

oxidative stress, 8-oxodG, prostate cancer
Klin. urol. 2012; 8 (2-3): 90-94

Ročník 2012  Témy časopisu Clinical urology 2 / 2012

Overview works

Petr Macek1, Květoslav Novák1, T. Tomáš Zelinka2, Jiří Widimský2, Tomáš Hanuš1
Dalibor Ondruš1, Martina Ondrušová2

Vladimír Bartoš1, Oľga Zacharová1, Dušan Pokorný1, Roman Mráz2, Juraj Mikuláš2, Peter Laurinc2
Juraj Mikuláš, Peter Laurinc, Roman Mráz, Pavel Kažík
Ján Kliment
Ján Kliment

Monika Kmeťová - Sivoňová1, Ľubica Stankovičová1, Marta Vilčková1, Dušan Dobrota1, Mária Kovalská1, Zuzana Tatarková1, Martina Pavlíková1, Ján Kliment2

Case Studies

Oldřich Šmakal1, Milan Král1, Vladimír Študent1, Hana Flögelová2
Vladimír Bartoš1, Roman Mráz2, Oľga Zacharová1, Juraj Mikuláš2
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Nie sú dostupné žiadne voľne dostupné články
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Which of following factors is not related to rosacea?
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Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné