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Časopis Clinical urology – Článok Expression of erythropoietin in oncogenesis of clear cell renal cell carcinoma

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné
Téma: 

Expression of erythropoietin in oncogenesis of clear cell renal cell carcinoma

Lucia Mésarošová1, Ján Švihra2, Jasna Šranková1, Ján Kliment2, Ján Kyselovič1, Ján Ľupták2, Pavol Slávik3, Peter Ochodnický4

Introduction and objectives: Clear cell renal cell carcinoma (CCRCC) represents 75-80 % of all histological subtypes and it is the most commonly occurring subtype of renal adenocarcinoma. Tissue hypoxia is the result of an imbalance in the supply of oxygen to the tissues, and its metabolic consumption. Hypoxia leads to activation of several genes encoding proteins involved in angiogenesis, erythropoiesis, and glucose metabolism. Aim of this study was to investigate the expression of erythropoietin (EPO) in tumour tissue after hypoxic conditions, with the aim to highlight its role in the development of clear cell renal cell carcinoma. Material and methods: In patients after radical nephrectomy tumour and control tissues were sampled, in which there were monitored changes in the expression of HIF-1α by immunoblot analysis and expression of EPO and EPOR using RT-PCR method. Results: We have observed neither change in HIF-1α expression nor in EPOR expression in tumour tissue compared with control one. By RT-PCR method we determined the expression of EPO, where our results showed an increased expression of EPO in tumours compared to control tissue. Conclusion: The function of EPO overexpression by cells in CCRCC has not been known yet, as only in 5 % of patients with RCC erythrocytosis is reported. The excessive EPO production in CCRCC cells is probably related to its proangiogenic, antiapoptotic and proliferative processes during tumourigenesis in neoplastic diseases.

CCRCC, HIF-1α, EPO, EPOR
Klin. urol. 2013; 9 (1): 34-37

Ročník 2013  Témy časopisu Clinical urology 1 / 2013

Paul Abrams, Maurizio Brausi, Stefan Buntrock, Thomas Ebert, Hashim Hashim, Hans-Göran Tiselius, Jean-Jacques Wyndaele

Overview works

Dalibor Ondruš1, Martina Ondrušová2,3
Jozef Marenčák

Terezia Višvaderová1, Martin Jankovich1, Frederico Manuel Figueiredo Goncalves1,2, Marián Hladík2, Peter Kertes2, Miroslav Helbich3

Jozef Marenčák

Lucia Mésarošová1, Ján Švihra2, Jasna Šranková1, Ján Kliment2, Ján Kyselovič1, Ján Ľupták2, Pavol Slávik3, Peter Ochodnický4
Silvia Mahmood1, Monika Kmeťová Sivoňová1, Dušan Dobrota1, Marta Vilčková1, Róbert Dušenka1,2, Ján Kliment2

Case Studies

Peter Čech
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CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ján Kliment, CSc.

MEMBERS OF THE EDITORIAL BOARD
prof. Andrzej Borówka, M.D., PhD.
prof. MUDr. Ján Breza, DrSc.
prof. MUDr. Peter Bujdák, PhD.
prof. MUDr. Tomáš Hanuš, DrSc.
doc. MUDr. Ladislav Jarolím, CSc.
doc. MUDr. Ján Ľupták, PhD.
doc. MUDr. Jozef Marenčák, PhD.
doc. MUDr. Ivan Minčík, PhD.
prof. MUDr. Dalibor Ondruš, DrSc.
prof. Imre Romics, M.D., PhD.
doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
prof. MUDr. Ladislav Valanský, PhD.
doc. MUDr. František Záťura, PhD.
MUDr. Peter Zvara, PhD.

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prof. MUDr. Ján Švihra, PhD.

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Citation means in general: the surname of the author (authors), title of the work, year of issuing, volume, pages.
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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285: 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Which of following factors is not related to rosacea?
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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

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Send contributions in the e-mail to the address: paulenova@amedi.sk
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné