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Časopis Clinical urology – Článok Assessment of the transrectal prostate biopsy results

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné
Téma: 

Assessment of the transrectal prostate biopsy results

Peter Čech1, Ján Ľupták2, Peter Slezák3

Objective: 1. To characterise and compare patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) in terms of age, prostate volume, prostate specific antigen (PSA). 2. To establish a relationship between capture/PCa incidence, localization, laterality, number of samples, biopsies performed/biopsies repeated, detect the differences in the incidence of PCa in the prostate and on this basis to create a “map” of the PCa incidence in the prostate gland. 3. To verify the effect of age on PSA levels and on the prostate volume respectively. Material and Methods: The study included patients examined at the Urology Clinic of University Hospital Martin (UHM) in the years 2007-2008 and at the Department of Urology of Hospital Bojnice in the years 2009-2012, who were indicated for prostate biopsy (PB) due to positive digital rectal examination (DRE) and/or who had higher PSA level (> 4 ng/ml). We excluded patients with a PSA greater than 50 ng/ml and patients where less than 8 samples have been taken. The total number of examined patients meeting criteria was 474 out of which 186 (39.2 %) have been examined at the Department of Urology of the Hospital Bojnice and 288 (60.8 %) at the Department of Urology of UHM respectively. The average age of examined patients was 66.3 years (SD ± 8.3 years). Results: PCa was diagnosed in 233 (49.2 %) out of 474 patients. Patients with bioptically verified PCa were on average older than 68.2 (SD ± 8.5) years and with a smaller volume of the prostate (median = 33 ml) compared to the age of patients with negative PB 64.5 (SD 7.7) years, median prostate volume 40 ml. No significant effect of the laterality and the number of samples on the presence of PCa has been observed (P = 0.590). We have bioptically confirmed the highest incidence of PCa at apex (38.1 %), lower in the base (33.2 %) and the lowest (28.7 %) in the middle of the prostate. We have confirmed statistically significantly higher detection of PCa in the laterally taken samples of the prostate (in 10 collected samples P = 0.049 and in 12 collected samples P = 0.027). Positive correlation between PSA values and increasing age was statistically significant (P < 0.0001), and likewise between the volume of the prostate with increasing age (P = 0.001). The correlation between increasing number of positive samples and increasing Gleason score (GS), P < 0.001 was also statistically significant. Conclusion: The obtained results suggest that the methods used for the diagnosis of PCa (DRE, transrectal ultrasonography – TRUS, PSA) alone do not provide sufficient diagnostic validity. Therefore, it is essential for early detection of PCa to combine these diagnostic modalities. Sampling of the prostate should be directed into the lateral and apical regions of the prostate respectively.

prostate biopsy, prostate cancer, transrectal ultrasound, PSA
Klin. urol. 2013; 9 (2-3): 102-108

Ročník 2013  Témy časopisu Clinical urology 2 / 2013

Martina Ondrušová1,2,3, Veronika Šťastná4, Dalibor Ondruš5
Štefan Galbavý
Juraj Fillo
Jana Obertová
Ján Ľupták, Ján Švihra, Boris Eliáš
Vladimír Bartoš1, Juraj Mikuláš2, Roman Mráz2
Peter Čech1, Ján Ľupták2, Peter Slezák3

Case Studies

Peter Čech, Romana Hubináková, Jana Mrážiková

M. E. Lipkin a G. M. Preminger

Overview works

Milan Šobek
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doc. MUDr. Ladislav Jarolím, CSc.
doc. MUDr. Ján Ľupták, PhD.
doc. MUDr. Jozef Marenčák, PhD.
doc. MUDr. Ivan Minčík, PhD.
prof. MUDr. Dalibor Ondruš, DrSc.
prof. Imre Romics, M.D., PhD.
doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
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3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
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The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

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Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné