Jozef Marenčák, Rudolf Moro, Eduard Králik, Patrícia Rusková
Introduction: The overall incidence of malignancies during pregnancy is 2.35 in 10 000 pregnant women. Urological tumours occur in pregnancy rare – with an incidence of 1 in 1000 pregnancies. However, there is no evidence of an increased incidence of malignant neoplasm in pregnant women. Objective: Retrospective evaluation of occurrence of symptoms (particularly macroscopic haematuria), diagnosis and treatment of urological tumours in pregnant women and provide an overview of the current management of urinary tract tumours diagnosed during pregnancy. Material and methods: From 1. 1. 1985 to 31. 12. 2013 a total 10 pregnant women (mean age 28.5, range 21-41 years) were examined and treated for malignancies of the urinary tract in the Department of Urology, University Hospital Skalica. Urological malignancies were: bladder tumours (6 x), kidney cancer (2 x), cancer of the urethra (1 x) and urothelial neoplasm of ureter (1 x). Macroscopic, painless haematuria was present in 7 from 10 pregnant women afflicted with malignant tumours of the urinary tract. The diagnosis was established based on history, clinical signs, laboratory tests, ultrasonography, magnetic resonance imaging, cystoscopy, and in one case by using flexible ureteronoscopy. The presence of urological tumours was confirmed in two women in the first trimester and the remaining 8 women in the second and third trimesters of pregnancy. Treatment of cancer during pregnancy: transurethral resection and coagulation of bladder tumours, electrocoagulation of urothelial tumour in the ureter and urethra cancer resection. Cancer of the kidney and retroperitoneum were solved in a standard way after birth. Benign tumours of the urinary system were shown in 11 women (mean age 24, range 19-43 years): urethral caruncle (4 x), angiomyolipoma of the kidney (2 x), fibroepithelial polyp of bladder (2 x), granuloma gravidarum urethrae (2 x) and retroperitoneal leiomyoma (1 x). Results: All women with urological malignancies detected and treated during pregnancy or shortly after birth are still oncologically okay and 8 from 10 is still regularly inspected. In one woman with renal angiomyolipoma urgent nephrectomy for retroperitoneal haemorrhage was needed 10 months after birth. Conclusions: The diagnosis of cancers of the urinary tract in pregnancy is not always easy. Tumour type and duration of pregnancy makes the choice and timing of treatment options to minimize risk for both – the mother and the foetus. It is alwaysnecessary interdisciplinary cooperation and consent (with proposed – almost always individual) approach obtained from a well – informed patient and her family.