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Časopis Clinical urology – Článok Association between p53 and p21 gene polymorphisms and prostate cancer risk in the slovak population

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné
Téma: 

Association between p53 and p21 gene polymorphisms and prostate cancer risk in the slovak population

Monika Kmeťová-Sivoňová1, Marta Vilčková1, Svetlana Grobarčíková2, Jana Jurečeková1, Dušan Dobrota1, Ján Kliment2

Introduction and Aims: The tumour suppressor protein p53 and its downstream effector p21 are thought to play major roles in the development of human malignancy. Polymorphic variants of p53 and p21 genes have been associated with cancer susceptibility, but few studies have investigated their effect on prostate cancer risk. The purpose of this study was to detect three polymorphisms of the p53 (codon 72) and p21 genes (C98A, C70T), to assess their relationship and to evaluate the correlation between p53 and p21 polymorphisms and clinicopathological findings in prostate cancer. Material and Methods: We genotyped three single nucleotide polymorphisms (SNPs) in p53 and p21 among 300 prostate cancer patients and 446 healthy controls by using PCR-RFLP (polymerase chain reaction restriction fragment length polymorphism analysis). Relative risk of prostate cancer for p53 and p21 genotypes was estimated using χ2 method. Results: We have found that each polymorphism individually was unrelated to prostate cancer risk, combination of the p53 codon 72 Arg/Pro and p21 C98A CA genotypes was associated with a significant 51 % decreased risk of prostate cancer (p < 0.05). We observed a significant decreased risk of prostate cancer associated with the p21 C98A CA genotype in patients with serum PSA levels ≥ 10 ng/ml in comparision with patients with wild type p21 C98A genotype and serum PSA levels ≤ 10 ng/ml (p < 0.05). Conclusions: Taken together, this is the first study to show that a combination of variant genotypes of p53 codon 72 and p21 C98A may modify prostate cancer risk.

p53, p21, gene polymorphism, prostate cancer
Klin. urol. 2014; 10 (1): 37-42

Ročník 2014  Témy časopisu Clinical urology 1 / 2014

Vladimír Bartoš1, Juraj Mikuláš2, Roman Mráz2
Jozef Marenčák, Rudolf Moro, Eduard Králik, Patrícia Rusková

Jozef Marenčák, Rudolf Moro, Eduard Králik, Dymitry Lapatko
Michal Peteja, Ivan Viľcha, Ivan Minčík, Richard Ľuník

Vincent Nagy1, Ivica Lazúrová2, Ingrid Dravecká2, Jagienka Jautová3, Janette Baloghová3, Ladislav Valanský1, Ľubomír Lachváč1
Monika Kmeťová-Sivoňová1, Marta Vilčková1, Svetlana Grobarčíková2, Jana Jurečeková1, Dušan Dobrota1, Ján Kliment2

Jaroslav Beck1, Tatiana Baltesová2, Ľuboš Tešľa1, Štefan Hulík3, Erik Tóth3, Vincent Nagy1, Ladislav Valanský1, Ľuboslav Beňa2, Peter Závacký3

Ľuboš Tešľa, Vincent Nagy
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Period 3x per year
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The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné