Vladimír Bartoš1, Juraj Mikuláš2, Oľga Zacharová1, Roman Mráz2
Primary malignant neoplasms of the penis are relatively infrequently diagnosed in a routine clinical practice. The vast majority of them represents a squamous cell carcinoma, other malignancies occur very sporadically. The authors of the article describe a case report of a 38-year old man, who was diagnosed to have a nodular malignant melanoma on the glans penis. The tumour corresponded to the pathological stage pT4b and was accompanied by a high mitotic and proliferative activity. After its surgical removal, the patient was clinically investigated and a high dose interferon alfa-2b adjuvant therapy was applied. 10 months later, right sided lymphadenectomy was performed due to enlargement of the lymph nodes. Biopsy revealed a massive metastatic infiltration of one lymph node. Shortly after the left sided lymphadenectomy was done without an apparent metastatic involvement. Malignant melanoma of the penis is a unique oncological entity. Our case report confirms literature data, that the most cases are diagnosed in an advance stage, often with regional lymph node metastases. Therefore, from a prognostic point of view, early diagnosis and initiation of a therapy is crucial, as well as a subsequent follow up and a further careful monitoring of the patient.