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Časopis Clinical urology – Článok Radium 223Ra in the treatment of metastatic prostate carcinoma

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné
Téma: 

Radium 223Ra in the treatment of metastatic prostate carcinoma

Ján Kliment st., Hubert Poláček, Ivan Režňák

Almost all patients with metastatic castration-resistant prostate carcinoma have bone metastases which are accompanied
with pain, occurrence of painful bone complications and lowering of quality of life and shortened survival. In recent
years, several preparations, which prolong the survival and improve the quality of life in patients have been implemented
to clinical use. Here also belongs radium -223. Radium-223 is an alpha particle-emitting nucleotide, which reminds
calcium with its properties. It replaces it in the compound with hydroxyapatite in the places of increased bone changes
in bone metastases and their surroundings. A high energy and low penetration in comparison with beta particles are
characteristic for alpha particles. Radiation of alpha emitting particles causes irreversible double DNA breaks and a subsequent
strong cytotoxic effect in the sites in which the metastatic tumour cells occur. Distribution into soft tissues is limited.
The clinical study ALSYMPCA, based on which the clinical use of radium -223 showed improvement in the overall
survival and delay in symptomatic bone complications regardless the previous treatment with docetaxel. Radium-223
is perfectly tolerated by patients, has an excellent profile and low incidence of haematological complications. In the paper,
the present clinical studies with radium-223 are stated, as well as contemporary experience, practical aspects of radium-
223 and its place in nowadays possibilities of treatment for metastatic castration-resistant prostate carcinoma.

radium-223, castration-resistant metastatic prostate carcinoma, bone metastases
Klin. urol. 2016; 12 (1): 13-17

Ročník 2016  Témy časopisu Clinical urology 1 / 2016

Vladimír Baláž, Jozef Babeľa, Pavel Bican, Terézia Stančoková
Ján Kliment st., Hubert Poláček, Ivan Režňák
Ján Šulgan, Martin Jonáš, Roman Tomaškin, Ján Švihra, Eliáš Boris, Pavol Slávik, Ján Ľupták
Jozef Marenčák

Zuzana Nosáľová, Vincent Nagy, Miroslav Iláš , Ľubomír Lachváč
Jozef Marenčák, Eduard Králik, Patrícia Rusková, Lenka Kotorová, Michaela Trabalíková

Ján Breza ml., Zuzana Žilinská, Martin Chrastina, Miroslava Sersenová, Branislav Trebatický,Peter Bujdák, Ján Breza st.

CASE STUDIES

Marek Gojdič, Ján Breza, ml., Katarína Macháleková, Štefan Galbavý, Ján Breza, st.
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CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ján Kliment, CSc.

MEMBERS OF THE EDITORIAL BOARD
prof. Andrzej Borówka, M.D., PhD.
prof. MUDr. Ján Breza, DrSc.
prof. MUDr. Peter Bujdák, PhD.
prof. MUDr. Tomáš Hanuš, DrSc.
doc. MUDr. Ladislav Jarolím, CSc.
doc. MUDr. Ján Ľupták, PhD.
doc. MUDr. Jozef Marenčák, PhD.
doc. MUDr. Ivan Minčík, PhD.
prof. MUDr. Dalibor Ondruš, DrSc.
prof. Imre Romics, M.D., PhD.
doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
prof. MUDr. Ladislav Valanský, PhD.
doc. MUDr. František Záťura, PhD.
MUDr. Peter Zvara, PhD.

PROFESSIONAL EDITOR
prof. MUDr. Ján Švihra, PhD.

EDITOR-IN-CHIEF
Ing. Danica Paulenová
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SECTIONS

OVERVIEW PAPERS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy. Maximum extent is 7 pages of text (font ARIAL or TIMES, font size 12, line spacing 1.5). In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office.

ORIGINAL PAPERS
Structuring: introduction, clinical group and methods, results, discussion, conclusion, bibliography

DIAGNOSTIC AND THERAPEUTICAL ALGORITHMS
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CASE STUDY
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Write the paper on computer in any common text editor.
write full length of lines (do not use ENTER at the end of a line)
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1. An accurate paper title, names and surnames of all authors including titles, authors` workplace. The first author address including the phone number, fax and e-mail address.
2. Summary - structured abstract: goal of work, material and methods (do not state the name of the workplace), results, conclusion
3. Key words - in the extent of 3-6.
Write in 1st or 3rd person singular or plural (unify according the type of an article).
4. English translation: the title of the paper, summary, key words 5. Text
If you insert pictures into a document, send also their original files in "jpg" format, create graphs in Excel and send also their original files. If you send photo documentation via post office, please, send just high-class originals. Mark each original by a number, under which it is mentioned in the text. Write in 1st or 3rd person singular or plural (unify according the type of an article). In the text do not use highlighting of the text as e.g. underlined text, bold, with exception of titles, references to pictures, tables, graphs.

6. Bibliography
Citations are numbered chronologically in bold, references in the text are stated by the number of citations in parentheses.
Citation means in general: the surname of the author (authors), title of the work, year of issuing, volume, pages.
Do not use "ét al.", but state all authors.

Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285: 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981:15-27.

Do not use dots after first names in citations. Do not use colon but dot after names of authors. Use semi-colon after the year of publishing, colon is before pages.

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

Which of following factors is not related to rosacea?
a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

All published papers are paid.

Send contributions in the e-mail to the address: paulenova@amedi.sk
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné