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Časopis Clinical urology – Článok Current role of bone scintigraphy with technetium labelled bisphosphonates (99mTc-MDP, 99mTc-HDP) in the diagnostics of bone metastases in prostate cancer

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné
Téma: Urological oncology

Current role of bone scintigraphy with technetium labelled bisphosphonates (99mTc-MDP, 99mTc-HDP) in the diagnostics of bone metastases in prostate cancer

Hubert Poláček, František Trudič, Daniel Evin, Ján Kliment

The basic information about a well-established nuclear medicine imaging method, still frequently indicated in prostate
cancer, is presented in the review en_article. Problematic aspects of the bone scintigraphy outcomes are explained,
i.e. impracticable image quantification, low specificity, false negativity in lytic/marrow lesions, superscan and
flare response phenomenon. The article presents the shifts in the clinical recommendations for bone scintigraphy
which result from the advance of predictive modelling studies, new generation imaging techniques and the trials of
the new treatments especially in the metastatic castration resistant stage of the disease.
The accumulation rate of the bone-seeking radiopharmaceuticals (bisphosphonates labelled with 99mTc reflects well
the biological aggressiveness of metastatic lesions, while the fraction of the affected skeleton is proportional to the
risk of severe complications and bone events. In the advanced stages of the disease, which are still common, classic
bone scintigraphy findings are usually sufficient to guide the treatment. Therefore, the bone scintigraphy does
not need to be replaced by more accurate but significantly more expensive MRI and PET/CT methods in most clinical
settings. New generation imaging methods are nowadays recommended for the localization of recurrence after
the treatments with curative intent, or to better specify the equivocal bone scintigraphy findings.

prostate cancer, bone scintigraphy, bone metastases, staging, restaging, follow-up, treatment response
Klin urol 2018; 14 (3): 100 – 109

Ročník 2018  Témy časopisu Clinical urology 3 / 2018

Urological oncology

Ján Kliment, Monika Kuzma
Andrej Vondrák
Hubert Poláček, František Trudič, Daniel Evin, Ján Kliment

Functional urology

Magdaléna Hagovská, Ján Švihra, Alena Buková, Agata Hrobacz, Dana Dračková, Viera Švihrová, Iveta Nagyová
Anna Kružlíková
Jozef Marenčák

Kazuistiky

Vladimír Bartoš, Juraj Mikuláš, Dušan Pokorný, Pavol Lamoš
Ľuboš Tešľa, Igor Milichovský, Michal Kmak
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Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ján Kliment, CSc.

MEMBERS OF THE EDITORIAL BOARD
prof. Andrzej Borówka, M.D., PhD.
prof. MUDr. Ján Breza, DrSc.
prof. MUDr. Peter Bujdák, PhD.
prof. MUDr. Tomáš Hanuš, DrSc.
doc. MUDr. Ladislav Jarolím, CSc.
doc. MUDr. Ján Ľupták, PhD.
doc. MUDr. Jozef Marenčák, PhD.
doc. MUDr. Ivan Minčík, PhD.
prof. MUDr. Dalibor Ondruš, DrSc.
prof. Imre Romics, M.D., PhD.
doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
prof. MUDr. Ladislav Valanský, PhD.
doc. MUDr. František Záťura, PhD.
MUDr. Peter Zvara, PhD.

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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285: 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Which of following factors is not related to rosacea?
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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

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Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Predplatné