Téma: Overview works

Important role of bnp and nt-probnp in cardiovascular risk prediction

Peter Lesný, Eva Goncalvesová

B-type natriuretic peptide (BNP) and its N-terminal fragment (NT-proBNP) are biomarkers of heart failure (HF). They are released from cardiomyocytes in response to left ventricular pressure and/or volume overload. Originally, natriuretic peptides were utilized in the diagnosis of HF in patients with acute onset dyspnoe of unknown etiology. They have a good correlation with left ventricular dysfunction, NYHA class, and prognosis of patients with HF. There are good prospects for the use of BNP and NT-proBNP in individually tailoring the treatment of HF. Apart from that, B-type natriuretic peptides are independent predictors of prognosis of patients with acute coronary syndromes, stable coronary artery disease, and aortic stenosis.
Keywords: BNP, NT-proBNP, heart failure, prognosis

Ročník 2007  Témy časopisu Cardiology for practice 3 / 2007

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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285: 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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In which patients, after overcoming of a thromboembolic cerebral or peripheral event, the least suitable catheter closure is foramen ovale patents:
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b. paroxysmal fibrillation of the atrium
c. aneurysm of the atrium septum
d. origination of an event after cough

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