Téma: Overview works

Crohn’s disease – current status of its imunopathogenesis and imunotherapy

Milan Buc

Crohn’s disease belongs to organ - specific autoimmune diseases. Yet still unknown microbial or environmental antigens start complex autoimmune processes resulting in an intestine wall damage. T - cells (TH1) play a principle role in immunopathological reactions, esp. in their initial phases. Crohn’s disease is genetically determined; out of many genes involved, the NOD - 2 is of paramount importance. NOD - 2 encodes an intracellular pattern recognition receptor (PRR) that inhibits intracellular signalling induced by TLR - 2 ligation by peptidoglycan present in the cell wall of many bacteria. Its insufficient activity, caused by the NOD - 2 mutation frequently observed in the Crohn’s disease patients, leads to uncontrolled inflammatory processes. They are further supported by an enhanced activity of the transcription factor Smad - 7 what results in insufficient immunosuppressive activity of TGF - β. Understanding of the Crohn’s disease immunopathogenesis has enabled a biological therapy by monoclonal antibodies against the proinflammatory cytokine TNF (infliximab) and the α4β1 - integrin (natalizumab), respectively.

Ročník 2004  Témy časopisu Gastroenterology for practice 4 / 2004

CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Rudolf Hyrdel, CSc.

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Marian Bátovský, CSc., mim. prof. SZU
prof. MUDr. Juraj Bober, CSc.
MUDr. Ivan Bunganič
prof. MUDr. Petr Dítě, DrSc.
doc. MUDr. Martin Huorka, CSc.
doc. MUDr. Peter Makovník, CSc.
MUDr. Juraj Májek, PhD.
prof. MUDr. Peter Mlkvý, CSc.
MUDr. Tomáš Šálek
MUDr. Renata Szépeová, PhD.
prof. MUDr. Anton Vavrečka, CSc.
MUDr. Mária Zakuciová

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Ing. Danica Paulenová
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SECTIONS

SURVEY WORKS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy.
Maximum size is 8 pages (font size 12, line spacing 1.5) with maximum five pictures (graphs). In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office. Write the article with focus on its practical use for gastroenerologists and specialists from other disciplines interested in gastroenterology.

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Examples of citations:
1. Vaughan TL, Davis S, Kristal A, et al. Obesity, alcohol and tobacco risk factors for cancers of esophagus and gastric cardia :adenocarcinoma versus squamous cell carcinoma Cancer Epidemiol Biomarkers Prev 1995; 4: 85-92.
2. Gao YT, McLaughlin JT, Gridley T, et al. Risk factors for esophageal cancer in Shanghai, China. Role of diet and nutrients. Int J Cancer 1994; 58: 197-202.
3. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.

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AUTODIDACTIC TEST

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

Origination of pigment stones is related to:
a. acute haemolysis
b. chronic haemolysis
c. hypercalcaemia
d. hyperlipoproteinaemia

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are double reviewed.

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