Téma: Overview works

Peutz jeghers syndrom – diagnostics and management

Ján Ušák, Juraj Hromec, Zdena Bartošová, Ivan Vojtech, Vanda Ušáková, Tibor Kružliak

Peutz Jeghers syndrom (PJS) detected by J.L.A. Peutz (1921) and later completely described by H. Jeghers (1944) is an autosomal dominant disorder characterised by intestinal hamartomatous polyps and mucocutaneous melanocytic macules. Genetic backgroud of the disease was explained by Hemminki (1998). Expresion of this rare disease in our population is unknown. In comparison with usual population patients with PJS have 15 times incerased risk of neoplasms. Characteristic pathology of Peutz - Jeghers polyps is extensive smooth muscle arborization throughout the polyp, with the appearance of pseudoinvasion because some of the epithelial cells, usually from benign glands, are surrounded by the smooth muscle.

Ročník 2005  Témy časopisu Gastroenterology for practice 1 / 2005

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2. Gao YT, McLaughlin JT, Gridley T, et al. Risk factors for esophageal cancer in Shanghai, China. Role of diet and nutrients. Int J Cancer 1994; 58: 197-202.
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Origination of pigment stones is related to:
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