Téma: Overview works

Our experience with biological therapy in inflammatory bowel disease ( ibd)

Tomáš Zamborský, Barbora Desatová, Igor Páv, Táňa Novotná

Biological therapy represents new possibilities of conservative treatment of IBD. It has led to a significant reduction in the need of surgical treatment of the patients and resulted in a significant improvement in the quality of their lives. The Centre of biological therapy of Gastroenterology clinic of SZU in Bratislava uses two agents of protein nature at present. The agents are prepared by the method of genetic engineering, infliximab – chimeric monoclonal antibody to TNF-alpha and adalimumab – recombinant monoclonal antibody to TNF-alpha. This article is dealing with our latest experience with the biological therapy of IBD in 59 patients, with its positive effects as well as its side effects. Actually there has been 45 patients under ongoing treatment – 28 with Crohn’s disease and 17 patients with ulcerative colitis. The most frequent indication for biological treatment were fistulas indicated in 8 patients with Crohn’s disease. The average value of CDAI in patients with Crohn’s disease before beginning of the treatment was 216. After administration of the induction dose of biological treatment it declined to 103. We noticed mucosal healing in 16/28 patients with Crohn’s disease and 12/17 patients with ulcerative colitis. Biological treatment was interrupted in 13/59 patients. Mostly due to allergy reactions (4 patients) and non-respondibility (4 patients).

Ročník 2009  Témy časopisu Gastroenterology for practice 4 / 2009

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