Ivan Bunganič
About 50 % of population suffers from Helicobacter pylori infection, while this possibility rises with the age and lower socioeconomical status of inhabitants. In Slovakia, an average prevalence of Hp infection was decreased to 30 % during last years. At those infected ones, it is a co-factor of development of ulcer and duodenum (1-10 % of those who are Hp infected), gastric cancer (0.1-3 %), MALT (Mucosa Associated Lymphoid Tissue), gastric lymphoma (0.01 %). Hp eradication in “the first round” leads to recovery at 80 % of infected patients(1). About 20 % of the first trial failure can be attributed to various reasons, but the rising resistance of Hp bacteria to antibiotics belongs to the most serious ones, as well as probably other factors which we are still not able to define. This is the summary of data about Hp resistance to antibiotics, its reasons, and possibilities of empiric treatment of Hp infections, which are concluded by the author ´s personal data obtained during his practice.