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Časopis Gastroenterology for practice – Článok Hepatitis c treatment and liver transplantation

Gastroenterology for practice

Reviewed, postgraduate scientific medical journal.
Period 4x per year
ISSN:1336–1473
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gastroenterology for practice
Gastroenterology for practice
Reviewed, postgraduate scientific medical journal.
Period 4x per year
Predplatné
Téma: 

Hepatitis c treatment and liver transplantation

Ľubomír Skladaný, Svetlana Adamcová-Selčanová, Jozef Baláž, Erika Čellárová

Liver cirrhosis resulting from chronic hepatitis caused by hepatitis C virus (HCV) infection belongs to frequent indications for liver transplantation (LTx). HCV infection also represents a factor which significantly reduces 5- and 10-year patient survival after LTx in comparison with other, non-malignant indications. Besides the presence of HCV virus, its concentration in serum affects the post-transplant course of the disease. Therefore, possibilities of pre-transplant therapy are investigated. The therapy of patients awaiting LTx still comes up to against many obstacles – high frequency of serious adverse effects, inconsistency of dosing schemes and duration of the therapy, limited achievements of the therapy. A promising but yet not thoroughly investigated therapeutic area is the possibility of using cell growth factors, which might aid in overcoming the prohibitive adverse effects of the antiviral therapy and which could also increase its effectiveness. Infection of the transplanted hepatic graft is inevitable in all patients; viral load is usually higher than before LTx and a considerable part of the patients develop chronic C hepatitis with gradual progression to fibrosis; cirrhosis develops much faster than in the normal population and graft dysfunction and failure represents the most frequent cause of mortality in this group of patients. These are reasons for indicating the therapy after LTx. The concept of pre-emptive therapy initiated shortly after LTx, which was hoped to prevent progression of hepatitis, did not yield expected results and was gradually replaced with the concept of targeted therapy, postponed till the evidence of liver fibrosis. The basic therapeutic protocol is derived from the therapeutic protocols for treating chronic C hepatitis in otherwise normal population, and it includes monitoring the therapeutic effect evaluated by viral response in certain time frames; however, relevance of these indicators is being questioned. Although the effectiveness of antiviral therapy is lower when comparing with the normal population, it represents an unquestionable benefit for the patients after LTx. An exception is the post-transplant cholestatic C hepatitis, which is usually refractory to any treatment.

hepatitis C, Liver transplantation, Antiviral therapy
Gastroenterol. prax 2011; 10 (1): 33-39

Ročník 2011  Témy časopisu Gastroenterology for practice 1 / 2011

Ladislav Virág, Ivan Schréter
Ivana Valková, Pavol Kristian
Michal R. Piják, Peter Jarčuška, Marián Oltman, Veronika Csibová
Peter Jarčuška, Sylvia Dražilová, Martin Janičko, Eduard Veseliny
Ľubomír Skladaný, Svetlana Adamcová-Selčanová, Jozef Baláž, Erika Čellárová
Sylvia Dražilová
Štefan Hrušovský

Overview works

Michal Hošala1, Ľudovít Laca1, Ján Janík1, Jozef Hatok2, Marek Adámik1, Fani Mazyar1
Ingrid Marková, Jozef Květenský

Case Studies

Michal Hošala, Ľudovít Laca, Ján Janík, Marek Adámik, Mazyar Fani
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Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Rudolf Hyrdel, CSc.

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Marian Bátovský, CSc., mim. prof. SZU
prof. MUDr. Juraj Bober, CSc.
MUDr. Ivan Bunganič
prof. MUDr. Petr Dítě, DrSc.
doc. MUDr. Martin Huorka, CSc.
doc. MUDr. Peter Makovník, CSc.
MUDr. Juraj Májek, PhD.
prof. MUDr. Peter Mlkvý, CSc.
MUDr. Tomáš Šálek
MUDr. Renata Szépeová, PhD.
prof. MUDr. Anton Vavrečka, CSc.
MUDr. Mária Zakuciová

EDITOR-IN-CHIEF
Ing. Danica Paulenová
e-mail: paulenova@amedi.sk

GRAPHIC LAYOUT AND TYPESETTING
Lucia Vecseiová
e-mail: dtp@amedi.sk 

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ECONOMY AND SUBSCRIPTIONS
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PROFESSIONAL PROOFREADING
doc. MUDr. Soňa Kiňová, PhD.

LANGUAGE PROOFREADING
Mgr. Eva Doktorová

PROOFREADING OF ENGLISH TEXTS
Mgr. Jana Bábelová
SECTIONS

SURVEY WORKS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy.
Maximum size is 8 pages (font size 12, line spacing 1.5) with maximum five pictures (graphs). In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office. Write the article with focus on its practical use for gastroenerologists and specialists from other disciplines interested in gastroenterology.

CASE STUDY
Maximum extent is 7 pages. Structuring: summary, introduction, case study, discussion, conclusion, bibliography.

DIAGNOSTIC AND THERAPEUTICAL ALGORITHMS
Diagnosis and therapy processed into tables and schemes, with minimum text, with emphasis on conciseness and clarity.

REVIEWS FROM LITERATURE
News from foreign press, news in the field of diagnoses, therapies and other professional information, maximum extent is 2 pages.

MISCELLANEOUS
Reactions to articles, information on professional events, new books, reviews, conference reports, invitations and so on. Abstract written in Slovak or Czech from scientific work published here or abroad, not older than 1 year. Maximum extent is 1 page. Write the title of the paper in Slovak/Czech, authors, workplace, then title of the paper in English with full citation. Appropriate is to explain basic terms.


MANUSCRIPT ELABORATION

Write the paper on computer in any common text editor.
- write full length of lines (do not use ENTER at the end of a line)
- do not arrange the text into columns - do not do page make-up, tables put at the end of the paper.
- distinguish precisely numbers 1, 0 and letters l, O
- use always parentheses ( )
- explain abbreviations always when first used


MANUSCRIPT REQUIREMENTS

1. An accurate paper title, names and surnames of all authors including titles, authors` workplace. The first author address including the phone number, fax and e-mail address.
2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies). Write in 1st or 3rd person singular or plural (unify according the type of an article).
3. Key words - in the extent of 3-6 (only for overview papers and case studies).
4. English translation: paper title, summary, key words (only at overview papers and case studies)
5. Text
If you insert pictures into a document, send also their original files in "jpg" format, create graphs in Excel and send also their original files. If you send photo documentation via post office, please, send just high-class originals. Mark each original by a number, under which it is mentioned in the text. Write in 1st or 3rd person singular or plural (unify according the type of an article).
6. Bibliography
Citations are numbered chronologically in bold, references in the text are stated by the number of citations in parentheses. Use maximum 20 citations.

Examples of citations:
1. Vaughan TL, Davis S, Kristal A, et al. Obesity, alcohol and tobacco risk factors for cancers of esophagus and gastric cardia :adenocarcinoma versus squamous cell carcinoma Cancer Epidemiol Biomarkers Prev 1995; 4: 85-92.
2. Gao YT, McLaughlin JT, Gridley T, et al. Risk factors for esophageal cancer in Shanghai, China. Role of diet and nutrients. Int J Cancer 1994; 58: 197-202.
3. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.

Do not use dots after first names in citations. Do not use colon but dot after names of authors. Use semi-colon after the year of publishing, colon is before pages. If an author is one, two or three - it is necessary to state all. If there are more than three authors it is necessary to write first three and "et all", in Slovak and Czech citations "a spol."


AUTODIDACTIC TEST

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

Origination of pigment stones is related to:
a. acute haemolysis
b. chronic haemolysis
c. hypercalcaemia
d. hyperlipoproteinaemia

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are double reviewed.

All published papers are paid.

Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-patient practice of gastroenterologists and related specialisations.

Send contributions in the e-mail to the address: paulenova@amedi.sk
Period 4x per year
ISSN:1336–1473
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gastroenterology for practice
Gastroenterology for practice
Reviewed, postgraduate scientific medical journal.
Period 4x per year
Predplatné