Gabriela Senajová, Mária Zakuciová, Laura Gombošová, Marián Švajdler, Lýdia Frigová, Monika Hlebašková
Langerhans cell histiocytosis is an idiopathic disorder characterized by the proliferation of Langerhans cells. Literature describes incidence 1-2 cases per 1 million in the adult population. Langerhans cell histiocytosis is a rare disease of the paediatric population. Involvement of the gastrointestinal tract is very rare in LCH, especially in adults, with only a few isolated case reports available in literature. We present two cases of this rare disorder with manifestation in the small intestine and colon. The pathogenesis of histiocytosis is unknown. From the histopathological viewpoint, the demonstration of Birbeck granules by electron microscopy, but expression of the CD1a antigen on lesional cells also provides the basis for a definitive diagnosis.