Petr Dítě, Martin Blaho, Nina Dvořáčková, Jarmila Šímová, Tomáš Kupka, Adam Vašura, Kateřina Kapounková, Pavel Svoboda, Arnošt Martínek
The definition of chronic pancreatitis is still the subject of discussions. The latest definition, which was predominantly
a definition morphological, however, does not involve new knowledge mainly from genetics or molecular biology,
which at present significantly influences our view on the disease.
New mechanistic definition of chronic pancreatitis defines as chronic the pathological fibrotisation and inflammatory
pancreatic syndrome in individuals, who are carriers of some risk factors as factors genetic, environmental and other,
leading to gradual development of persistent parenchymal impairment of the gland.
Other common signs of chronic pancreatitis are fibrosis, gland atrophy, changes in the course and width of the pancreatic
outlet, algic syndrome, exocrine insufficiency, and dysplasia.
This definition and characteristics of the disease allow for the use of the rational approach to early diagnostics of the
disease, or also more precise disease definition and its prognosis.